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Table 1 Characteristics of patients with progressive ILD and a stable disease course

From: Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases

Variable

Progressive ILD (N = 50)

Stable disease (N = 47)

P value

Gender (male)

28 (56)

32 (68)

0.221

Age (years)

67.0 (60.8–69.3)

69.0 (60.0–75.0)

0.365

BMI (kg/m2)

28.2 (26.4–32.0)

28.1 (25.1–30.7)

0.264

Antifibrotic treatment

19 (38)

16 (34)

0.685

Immunosuppressive therapya

22 (40)

15 (32)

0.221

Never smoker

24 (48)

12 (25)

 

Former smoker

18 (36)

30 (64)

0.008*

Current smoker

8 (16)

5 (11)

 

Pack years (smokers only)

20.0 (10.0–30.0) 23/26

20.0 (15.0–30.0) 33/35

0.492

FVC %

78.5 (69.5–91.0)

83.0 (72.0–89.0)

0.267

FEV1%

82.0 (72.5–91.0)

83.0 (73.0–91.0)

0.829

DLCO %

61.5 (48.8–73.0)

63.5 (51.4–71.3) 46/47

0.498

White blood cells (109/L)

7.4 (6.0-9.3)

6.9 (5.5–8.1)

0.089

Hemoglobin (g/L)

137.5 (129.5-150.3)

143.0 (134.0-154.0)

0.196

Platelets (109/L)

243.5 (212.3-310.3)

241.0 (199.0-277.0)

0.067

Creatinin (umol/L)

75.0 (64.8–91.3)

76.0 (69.0–91.0)

0.530

GFR (ml/min/1.73m2)

84.0 (66.8–93.3)

84.0 (68.5–92.0)

0.847

LCQ total score

16.5 (13.5–19.1)

16.1 (12.4–18.4)

0.411

SGRQ total score

31.9 (14.5–51.7) 46/50

30.9 (16.4–38.4) 43/47

0.837

SOBQ total score

31.5 (7.50–51.0)

22.0 (11.0–40.0)

0.662

Ground-glass opacity score

3.0 (0.6–5.5)

1.5 (0.0-3.8) 41/47

0.105

Reticulation score

10.0 (7.9–12.0)

8.5 (6.0–10.0) 40/47

0.022

Emphysema score

0.0 (0.0–0.0)

0.0 (0.0-2.3) 44/47

0.158

Traction bronchiectasis score

3.5 (2.0-4.6)

2.5 (1.0–4.0) 44/47

0.070

Honeycombing score

0.0 (0.0-1.1)

0.0 (0.0-0.9) 44/47

0.157

UIP histopathology

12 (24)

10 (21)

0.749

UIP pattern on HRCTb

  

0.544

Definite UIP

2 (4)

2 (4)

 

Probable UIP

13 (26)

16 (34)

 

Indeterminate with UIP

22 (44)

14 (30)

 

Alternative diagnosis

13 (26)

15 (32)

 

Diagnosis

  

0.699

Idiopathic pulmonary fibrosis

32 (64)

31 (66)

 

Idiopathic nonspecific interstitial pneumonia

9 (18)

5 (11)

 

Hypersensitivity pneumonia

5 (10)

5 (11)

 

Unclassified ILD

3 (6)

2 (4)

 

Respiratory bronchiolitis associated ILD

1 (2)

-

 

Connective tissue disease associated ILD

-

1 (2)

 

Asbestosis

-

1 (2)

 

Cryptogenic organizing pneumonia

-

1 (2)

 

Fibrotic sarcoidosis

-

1 (2)

 
  1. Numbers are presented as N (%) or median (interquartile range, IQR). BMI = body mass index, DLCO % = diffusion capacity to carbon monoxide, FEV1% = forced expiratory volume in one second percent predicted, FVC % = forced vital capacity percent predicted, GFR = glomerular filtration rate, ILD = interstitial lung disease, LCQ = Leicester cough questionnaire, SGRQ = St George respiratory questionnaire, SOBQ = University of California shortness of breath questionnaire, UIP = usual interstitial pneumonia
  2. *P value between former smoker- never smoker. a. Including the use of oral corticosteroids, azathioprine, or mycophenolate. b. Re-categorized for this study, some of the results have been published previously [31]
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BMC Pulmonary Medicine

ISSN: 1471-2466

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