Table 1 Demographic and clinical characteristics of different groups of anti-MDA5 + patients with ILD
From: Neutrophil-to-lymphocyte ratio is a predictive marker for anti-MDA5 positive dermatomyositis
Overall | Survival | Un-survival | p | |
|---|---|---|---|---|
n | 195 | 140 | 55 | |
Age (mean ± SD) | 50.34 ± 10.56 | 49.38 ± 10.56 | 52.78 ± 10.24 | 0.038 |
Gender (male %) | 62 (31.79) | 41 (29.29) | 21 (38.18) | 0.303 |
Smoking (%) | 32 (16.41) | 18 (12.86) | 14 (25.45) | 0.055 |
Survival time (median [IQR]) | 13.50 [1.64, 32.56] | 24.13 [8.29, 40.02] | 0.77 [0.33, 2.50] | < 0.001 |
Clinical signs and symptoms | ||||
Heart failure (%) | 17 (8.72) | 9 (6.43) | 8 (14.55) | 0.127 |
Diabetes (%) | 17 (8.72) | 13 (9.29) | 4 (7.27) | 0.868 |
Fatty liver (%) | 39 (20.00) | 30 (21.43) | 9 (16.36) | 0.551 |
Hypertension (%) | 14 (7.18) | 7 (5.00) | 7 (12.73) | 0.116 |
Arthralgia (%) | 120 (61.54) | 91 (65.00) | 29 (52.73) | 0.155 |
Dyspnea (%) | 82 (42.05) | 49 (35.00) | 33 (60.00) | 0.003 |
Skin ulcer (%) | 23 (11.79) | 19 (13.57) | 4 (7.27) | 0.327 |
Gottron sign (%) | 120 (61.54) | 87 (62.14) | 33 (60.00) | 0.910 |
Heliotrope sign (%) | 101 (51.79) | 79 (56.43) | 22 (40.00) | 0.057 |
HRCT score (median [IQR]) | 84.00 57.00, 117.00] | 77.00 [54.75, 108.75.75] | 99.00 [70.00, 137.00] | 0.001 |
RPILD (%) | 63 (32.31) | 28 (20.00) | 35 (63.64) | < 0.001 |
Laboratory examination | ||||
RDW (median [IQR])L/L | 47.60 [44.80, 52.30] | 47.00 [44.20, 51.80] | 49.20 [46.15, 54.20] | 0.025 |
CK (median [IQR]) IU/L | 56.00 [31.50, 120.00] | 51.00 [30.00, 99.00] | 80.00 [45.50, 220.50] | 0.002 |
CRP (median [IQR]) (mg/L) | 5.87 [2.54, 16.75] | 4.27 [2.40, 10.48] | 15.30 [4.75, 34.40] | < 0.001 |
LDH (median [IQR]) IU/L | 321.00 [261.50, 441.50] | 301.00 [232.50, 365.25] | 443.00 [327.00, 658.00] | < 0.001 |
WBC (median [IQR])109/L | 5.59 [4.06, 7.44] | 5.42 [3.86, 7.06] | 6.47 [4.33, 8.63] | 0.066 |
PLT (mean ± SD) 109/L | 195.22 ± 71.39 | 197.66 ± 65.18 | 189.00 ± 85.55 | 0.174 |
Neutrophils (median [IQR]) 109/L | 4.27 [2.85, 5.74] | 4.03 [2.78, 7.18] | 4.81 [3.20 6.97] | 0.032 |
Lymphocytes (median [IQR]) 109/L | 0.79 [0.57, 1.09] | 0.88 [0.65, 1.12] | 0.72 [0.46, 0.97] | 0.008 |
NLR (median [IQR]) | 4.85 [3.41, 7.07] | 4.34 [3.15, 6.63] | 6.19 [4.70, 9.84] | < 0.001 |