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Fig. 10 | BMC Pulmonary Medicine

Fig. 10

From: Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis

Fig. 10

Knockdown of HMGB2 inhibited A549 cells colony-formation, tumorigrnicity and migration. A The protein level of HMGB2 and β-actin in A549 cells between HMGB2 knockdown group (shHMGB2-1 and shHMGB2-2) and shRNA negative control group (shNC) were determined by western blot assay. B Knockdown of HMGB2 inhibited A549 cells colony-formation. C Knockdown of HMGB2 inhibited A549 cells tumor volume in nude mouse model. D Knockdown of HMGB2 increased the number of A549 cells in the G0/G1 phase and decreased the number of cells in the G2/M phase. E Knockdown of HMGB2 inhibited A549 cells migration. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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BMC Pulmonary Medicine

ISSN: 1471-2466

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