The association between leukocyte telomere length and chronic obstructive pulmonary disease is partially mediated by inflammation: a meta-analysis and population-based mediation study

Wang, Tieshan; Jia, Zhaoqi; Li, Sen; Li, Yuxin; Yu, Tingting; Lu, Tao; Shi, Yuanyuan

doi:10.1186/s12890-022-02114-8

Table 1 Weighted characteristics of the study population by telomere length quartiles-NHANES 1999–2002

From: The association between leukocyte telomere length and chronic obstructive pulmonary disease is partially mediated by inflammation: a meta-analysis and population-based mediation study

Variable	Status	Overall			Telomere length												P value
		N	%	s.e.	Quartile 1			Quartile 2			Quartile 3			Quartile 4
		N	%	s.e.	N	%	s.e.	N	%	s.e.	N	%	s.e.	N	%	s.e.
Gender	Male	3102	49.19	0.63	861	50.54	1.29	807	50.57	1.36	720	47.03	1.51	714	48.95	1.33	0.26
Gender	Female	3276	50.81	0.63	734	49.46	1.29	787	49.43	1.36	875	52.97	1.51	880	51.05	1.33
Age	20–39 years	2322	40.02	1.13	232	18.22	1.51	475	32.71	1.98	690	44.75	2.24	925	58.40	2.60	< 0.01
	40–59 years	1976	38.72	0.90	427	38.00	2.12	549	43.62	1.69	535	40.03	1.95	465	33.74	1.90
	60–79 years	1666	17.97	0.69	694	34.82	1.85	466	20.17	1.55	321	13.82	1.16	185	7.27	1.00
	> 80 years	414	3.28	0.27	242	8.96	0.78	104	3.49	0.53	49	1.40	0.29	19	0.60	0.18
Race	White	3346	74.64	1.76	893	79.00	2.78	846	76.12	2.06	810	73.61	2.16	797	71.02	2.37	< 0.01
	Black	1033	8.71	1.00	209	6.67	0.95	237	7.62	1.30	243	8.07	0.90	344	11.80	1.58
	Others	1999	16.65	2.08	493	14.33	2.93	511	16.26	2.14	542	18.32	2.30	453	17.19	2.57
Education	< high school	2004	19.58	1.06	626	25.37	1.73	505	19.74	1.50	476	19.36	1.49	397	15.32	1.09	< 0.01
	= high school	1483	26.01	1.06	367	26.94	1.33	361	26.32	1.67	350	24.33	1.86	405	26.61	1.68
	> high school	2891	54.40	1.68	602	47.70	1.85	728	53.94	2.15	769	56.31	2.78	792	58.07	1.89
Poverty income ratio	< 1	1074	13.09	0.96	268	11.54	1.23	260	12.07	1.42	261	12.65	1.52	285	15.56	1.44	0.14
	1 ≤ PIR ≤ median	2659	35.87	1.40	714	38.42	2.03	663	36.48	1.58	647	34.07	2.21	635	35.07	2.07
	> median	2645	51.04	1.99	613	50.04	2.45	671	51.45	2.51	687	53.28	2.73	674	49.36	2.58
Body mass index	≥ 25	4380	65.30	0.89	1157	71.54	1.38	1102	66.56	1.78	1102	64.69	1.74	1019	60.09	1.74	< 0.01
Smoking	Yes	3118	50.27	1.41	843	53.74	2.11	791	51.37	1.81	761	49.46	1.46	723	47.45	2.63	0.07
Alcohol use	Yes	4374	73.32	2.08	1050	68.65	2.10	1089	72.41	2.56	1114	75.01	2.20	1121	76.07	3.14	0.02
Diabetes	Yes	590	6.36	0.39	223	10.29	0.86	158	6.81	0.90	118	4.96	0.69	91	4.33	0.62	< 0.01
High blood pressure	Yes	1877	25.30	0.91	604	34.45	1.74	505	26.55	1.54	437	24.51	1.54	331	18.09	1.24	< 0.01
Physical activity	Yes	3639	64.59	1.51	807	58.25	2.01	890	62.44	2.44	941	66.65	1.68	1001	69.32	1.94	< 0.01
COPD	Yes	455	7.89	0.46	162	11.78	0.92	116	8.82	0.87	95	6.02	0.77	82	5.88	0.52	< 0.01
Asthma	Yes	656	11.62	0.54	149	11.49	0.96	172	12.93	1.04	165	10.54	0.95	170	11.54	1.07	0.38

N Number; %, weighted percent; s.e. standard error; NHANES National Health and Nutrition Examination Survey
P values were calculated from Rao-Scott Chi-square tests

Back to article page

ISSN: 1471-2466

Contact us

Submission enquiries: bmcpulmonarymedicine@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Pulmonary Medicine

Contact us