Fig. 5
From: Altered expression of ACOX2 in non-small cell lung cancer
Methylation analysis of the ACOX2 promoter in NSCLC. The potential role of DNA CpG methylation was examined in LUAD and LUSC. A Analysis of methylation changes using UALCAN [37] and using stratification according to the default Beta-value cut-off for hypermethylation (0.7–0.5) the results suggest that hypermethylation is a significant element in LUSC, but not LUAD. Re-evaluation of methylation at the ACOX2 promoter in LUAD (B) and LUSC (C) using TCGA-Wanderer [46], showing clear differences in methylation at the promoter in LUSC. (*p < 0.05 is considered significant)