Table 5 Correlation between ACOX2 expression and markers of Tumour Mutational Burden

DNA Damage Response

(DDR) Pathway

BRCA1

 − 0.15

3 × 10^–4 ***

 − 0.42

3.5 × 10^–24 ***

ATM

0.03

0.49

0.12

0.0068 **

ATR

0.16

0.00023 ***

 − 0.25

4.3 × 10^–9 ***

CDK1

 − 0.24

2.2 × 10^–08 ***

 − 0.38

5.7 × 10^–20 ***

CHEK1

 − 0.2

2.5 × 10^–06 ***

 − 0.35

6.6 × 10^–17 ***

CHEK2

 − 0.047

0.27

 − 0.47

6.7 × 10^–31 ***

TP53

0.18

3.7 × 10^–05 ***

 − 0.096

0.027 *

Combined Signature

 − 0.1

0.02 *

 − 0.37

3.2 × 10^–21 ***

Mismatch excision repair (MMR) related genes

PMS2

0.091

0.034 *

 − 0.29

1.3 × 10^–11 ***

MLH1

0.22

2.4 × 10^–07 ***

0.21

1.3 × 10^–06 ***

MSH2

 − 0.051

0.24

 − 0.36

1.7 × 10^–17 ***

MSH3

0.099

0.021 *

 − 0.02

0.65

MSH6

 − 0.035

0.42

 − 0.44

4.8 × 10^–27 ***

PCNA

 − 0.19

5.6 × 10^–06 ***

 − 0.43

4.7 × 10^–26 ***

Combined Signature

0.0013

0.98

 − 0.37

3.2 × 10^–19 ***