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Fig. 5 | BMC Pulmonary Medicine

Fig. 5

From: METTL3 promotes non-small cell lung cancer (NSCLC) cell proliferation and colony formation in a m6A-YTHDF1 dependent way

Fig. 5

FRAS1 overexpression rescues the phenotype induced by METTL3 silence and CDON expression. A The positively associated genes with FRAS1 in NSCLC (pearson correlation r > 0.5). B The relationship between CDON and FRAS1 in NSCLC was analyzed using starbase (http://starbase.sysu.edu.cn/index.php). r = 0.505. P < 0.001. C The protein level of FRAS1 and CDON was analyzed by western blot in shMETTL3 HCC827 and NCI-H1975 cells with or without FRAS1 overexpression, or Ctrl cells. D CCK-8 assay was performed in shMETTL3 HCC827 and NCI-H1975 cells with or without FRAS1 overexpression, or Ctrl cells. *P < 0.05. **P < 0.01, ***P < 0.001. E Colony formation was analyzed in shMETTL3 HCC827 and NCI-H1975 cells with or without FRAS1 overexpression, or Ctrl cells

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BMC Pulmonary Medicine

ISSN: 1471-2466

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