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Fig. 6 | BMC Pulmonary Medicine

Fig. 6

From: METTL3 promotes non-small cell lung cancer (NSCLC) cell proliferation and colony formation in a m6A-YTHDF1 dependent way

Fig. 6

The enhanced FRAS1 m6A modification induced by METTL3 promotes cell proliferation of NSCLC cells. A The associated genes FRAS1, YTHDF1, CDON at mRNA level was analyzed in the following groups of HCC827 cells by qPCR. Ctrl, shscr + METTL3, shYTHDF1 + METTL3, shFRAS1 + METTL3. B The protein level of the above genes was measured by western blot in the following groups of HCC827 cells. Ctrl, shscr + METTL3, shYTHDF1 + METTL3, shFRAS1 + METTL3. C CCK-8 assay was analyzed in the following groups of HCC827 cells. Values are represented as means ± SD. (D) Colony formation was analyzed in the following groups of HCC827 cells. Ctrl, shscr + METTL3, shYTHDF1 + METTL3, shFRAS1 + METTL3. *P < 0.05 or **P < 0.01 or ***P < 0.001 indicates a significant difference between the indicated groups. ns, not significant

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BMC Pulmonary Medicine

ISSN: 1471-2466

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