Fig. 7

METTL3 induced FRAS1 promotes tumor growth in vivo. A Representative images of tumors originated from xenografted NCI-H1975 cells stably expressing Vector + sh-NC, METTL3 + sh-NC, METTL3 + sh YTHDF1, and METTL3 + sh-FRAS1 by subcutaneous injection. B The xenografte tumor model was constructed by using H1975 cells stably expressing Vector + sh-NC, METTL3 + sh-NC, METTL3 + sh YTHDF1, and METTL3 + sh-FRAS1 and the tumor volumn was measured at the indicated time points 7, 14, 21, 28 days after subcutaneous injection. C The tumor tissues were weighed after mice were sacrificed after 28 days. D The protein expression of METTL3, YTHDF1, and METTL3 was detected by western blot. *P < 0.05 or **P < 0.01 indicates a significant difference between the indicated groups