Table 2 Clinical characteristics associated with time to diagnosis in 409 patients with IPF
Time from symptom onset to diagnosis, months (IQR) | p-value | ||
|---|---|---|---|
Factor present | Factor absent | ||
Male sex (n = 313) | 24.0 (9.0–47.5) | 24.5 (8.3–49.8) | 0.70 |
Age at diagnosis < 60 years (n = 78) | 17.0 (6.8–45.0) | 25.0 (10.0–49.0) | 0.10 |
First-degree family member with pulmonary fibrosis (n = 116) | 19.5 (6.3–41.8) | 24.0 (10.0–49.0) | 0.05 |
Other family member with pulmonary fibrosis (n = 24) | 11.5 (5.3–57.8) | 24.0 (9.0–48.0) | 0.12 |
Any family member with pulmonary fibrosis (n = 125) | 19.0 (6.0–42.5) | 24.5 (10.3–49.0) | 0.03 |
Current smoker (n = 33) | 19.0 (5.5–39.0) | 0.07 | |
Former smoker (n = 298) | 26.0 (10.0–52.0) | ||
Never smoker (n = 78) | 23.0 (7.8–37.8) | ||
Significant exposure to asbestos, dusts, fumes, or radiation (n = 79) | 26.0 (10.0–49.0) | 23.0 (8.0–47.0) | 0.18 |
Gastro-oesophageal reflux (n = 149) | 24.0 (9.5–57.0) | 24.0 (9.0–46.5) | 0.49 |
Cardiovascular disease (n = 188) | 24.5 (8.0–52.0) | 24.0 (9.0–44.0) | 0.35 |
Chest X-ray done prior to start of symptoms (n = 96) | 17.0 (7.0–34.5) | 26.0 (10.0–50.8) | 0.01 |
Chest X-ray showing potential interstitial lung abnormalities (n = 56) * | 17.0 (7.0–27.8) | 21.0 (7.0–45.0) | 0.34 |
Symptoms started directly after infectious episode (n = 40) | 9.5 (5.0–27.8) | 25.0 (10.0–49.0) | < 0.001 |
Symptoms started directly after surgery (n = 5) | 12.0 (7.5–88.5) | 24.0 (9.0–48.0) | 0.99 |
Treatment with steroids prior to diagnosis (n = 103) # | 37.0 (19.0–78.0) | 18.5 (8.0–41.3) | < 0.001 |
Treatment with other immunosuppressant prior to diagnosis (n = 23) | 48.0 (26.0–84.0) | 23.0 (9.0–45.5) | 0.002 |
Other ILD diagnosis prior to diagnosis of IPF (n = 67) | 47.0 (26.0–83.0) | 19.0 (8.0–42.0) | < 0.001 |
Cardiology workup for symptoms prior to pulmonology visit (n = 45) | 23.0 (8.0–60.5) | 24.0 (9.0–48.0) | 0.59 |
Consensus diagnosis of IPF (n = 190) | 23.0 (9.0–49.0) | 24.0 (9.0–47.0) | 0.75 |
Received treatment with antifibrotic therapy after diagnosis | 25.0 (10.0–49.0) | 19.5 (7.0–42.0) | 0.17 |