Table 3 Univariate Cox analysis of dyspnea in patients with tuberculous lung damage
From: Long-term follow-up of tuberculosis-destroyed lung patients after surgical treatment
Variables | Follow-up time Person-years | Incidence rate, per 10 person-years | Total (n, %) | mMRC = 0 (n = 45, %) | mMRC ≥ 1 (n = 27, %) | HR (95%CI) | P value |
|---|---|---|---|---|---|---|---|
Sex | |||||||
Male | 92.5 | 1.1 | 28 (38.9) | 18 (64.3) | 10 (35.7) | Ref | |
Female | 166.4 | 1.0 | 44 (61.1) | 27 (61.4) | 17 (38.6) | 0.787 (0.358–1.729) | 0.551 |
Age group (years) | |||||||
< 60 | 242.4 | 1.0 | 67 (93.1) | 43 (64.2) | 24 (35.8) | Ref | |
≥ 60 | 16.5 | 1.8 | 5 (6.9) | 2 (40.0) | 3 (60.0) | 0.826 (0.240–2.845) | 0.762 |
BMI (kg/m2) | |||||||
< 18.5) | 38.4 | 1.3 | 12 (16.7) | 7 (58.3) | 5 (41.7) | Ref | |
18.5–24.9 | 191.0 | 1.0 | 52 (72.2) | 33 (63.5) | 19 (36.5) | 0.630 (0.234–1.694) | 0.360 |
≥ 25 | 29.5 | 1.0 | 8 (11.1) | 5 (62.5) | 3 (37.5) | 0.397 (0.093–1.693) | 0.212 |
Smoking history | |||||||
No | 230.2 | 1.1 | 62 (86.1) | 37 (59.7) | 25 (40.3) | Ref | |
Yes | 28.7 | 0.7 | 10 (13.9) | 8 (80.0) | 2 (20.0) | 0.712 (0.168–3.016) | 0.645 |
Comorbiditiesa | |||||||
No | 209.8 | 1.1 | 57 (79.2) | 34 (59.6) | 23 (40.4) | Ref | |
Yes | 49.1 | 0.8 | 15 (20.8) | 11 (73.3) | 4 (26.7) | 1.313 (0.443–3.890) | 0.623 |
mMRC | |||||||
0 | 80.1 | 1.2 | 20 (27.8) | 10 (50.0) | 10 (50.0) | Ref | |
≥ 1 | 178.8 | 1.0 | 52 (72.2) | 35 (67.3) | 17 (32.7) | 0.486 (0.170–1.389) | 0.178 |
Site of TDL | |||||||
Left lung | 203.9 | 0.9 | 56 (77.8) | 37 (63.2) | 19 (32.8) | Ref | |
Right lung | 55.0 | 1.5 | 16 (22.2) | 8 (50.0) | 8 (50.0) | 1.874 (0.817–0.296) | 0.138 |
Combined with other pathogenic bacteria | |||||||
No | 183.5 | 1.0 | 50 (69.4) | 31 (62.0) | 19 (38.0) | Ref | |
CPA or NTM | 75.4 | 1.1 | 22 (30.6) | 14 (63.6) | 8 (36.4) | 1.263 (0.550–2.899) | 0.583 |
Chest CT | |||||||
Number of contralateral lesions | |||||||
< 2 | 158.2 | 1.1 | 42 (58.3) | 25 (59.5) | 17 (40.5) | Ref | |
≥ 2 | 100.7 | 1.0 | 30 (41.7) | 20 (66.7) | 10 (33.3) | 1.132 (0.506–2.534) | 0.762 |
Spinal | |||||||
Cobb angles ≤ 5° | 156.7 | 0.6 | 40 (55.6) | 30 (75) | 10 (25) | Ref | |
Cobb angles > 5° | 102.2 | 1.7 | 32 (44.4) | 15 (46.9) | 17 (53.1) | 4.628 (1.953–10.964) | < 0.01 |
Lung function | |||||||
FVC, L | – | – | – | 2.4 ± 0.7 | 2.2 ± 0.6 | 0.621 (0.245–1.570) | 0.314 |
FVC% | |||||||
≥ 80% pred | 39.6 | 0.5 | 11 (15.3) | 9 (81.8) | 2 (18.2) | Ref | |
< 80% pred | 219.3 | 1.1 | 61 (84.7) | 36 (59.0) | 25 (41.0) | 2.183 (0.501–9.506) | 0.298 |
FEV1, L | – | – | – | 1.9 ± 0.6 | 1.7 ± 0.5 | 0.457 (0.157–1.332) | 0.151 |
FEV1/FVC, % | – | – | – | 78.1 ± 11.6 | 74.1 ± 11.6 | 0.970 (0.922–1.020) | 0.233 |
DLCO, L | – | – | – | 6.0 (4.8,6.9) | 5.1 (4.3,7.2) | 0.869 (0.646–1.168) | 0.352 |
DLCO% | |||||||
≥ 80%pred | 163.3 | 0.4 | 44 (61.1) | 37 (84.1) | 7 (15.9) | Ref | |
< 80%pred | 95.6 | 2.1 | 28 (38.9) | 8 (28.6) | 20 (71.4) | 2.794(1.168–6.683) | 0.021 |
Albumin, g/L | – | – | – | 39.4 ± 7.7 | 37.5 ± 5.2 | 0.957 (0.887–1.033) | 0.257 |
Albumin | |||||||
Normal | 203.7 | 1.0 | 54 (75.0) | 34 (63.0) | 20 (37.0) | Ref | |
Decreased | 55.2 | 1.3 | 18 (25.0) | 11 (61.1) | 7 (38.9) | 1.557 (0.654–3.706) | 0.317 |
Hemoglobin, g/L | – | – | – | 119.4 ± 20.7 | 122.3 ± 18.4 | 1.008 (0.983–1.033) | 0.541 |
Hemoglobin | |||||||
Normal | 240.5 | 1.1 | 67 (93.1) | 41 (61.2) | 26 (38.8) | Ref | |
Anemia | 18.4 | 0.5 | 5 (6.9) | 4 (80.0) | 1 (20.0) | 0.733 (0.097–5.560) | 0.764 |
Blood glucoseb | |||||||
PaO2, Torr | – | – | – | 98.3 (88.6,111) | 95.0 (86.7,111.8) | 0.994 (0.979–1.009) | 0.405 |
PaO2 | |||||||
Normal | 175.7 | 0.9 | 50 (92.6) | 35 (70.0) | 15 (30.0) | Ref | |
Decreased | 16.9 | 1.2 | 4 (7.4) | 2 (50.0) | 2 (50.0) | 1.607 (0.357–7.236) | 0.537 |
PaCO2, Torr | – | – | – | 42.0 (40.0,45.3) | 43.4 (40.6,46.3) | 1.088 (0.926–1.277) | 0.305 |
PaCO2 | |||||||
Normal | 137.1 | 0.8 | 39 (72.2) | 28 (71.8) | 11 (28.2) | Ref | |
Decreased | 55.5 | 1.1 | 15 (27.8) | 9 (60.0) | 6 (40.0) | 1.157 (0.424–3.153) | 0.776 |
Surgical excision range | |||||||
Lobectomy of lungs | 89.9 | 1.1 | 25 (34.7) | 15 (60.0) | 10 (40.0) | Ref | |
Pneumonectomy with or without pleura | 169.0 | 1.0 | 47 (65.3) | 30 (63.8) | 17 (36.2) | 0.657 (0.297–1.454) | 0.300 |