Fig. 3
From: Gene mutations in sporadic lymphangioleiomyomatosis and genotype–phenotype correlation analysis
Correlation of TSC2 mutation status/function type and DLCO %pred, 6MWD, and pneumothoraces. A The average DLCO %pred in the TSC2-mutated group was 54.39% versus 72.36% in the TSC2-naïve group (Welch’s t-test, p = 0.0243). B The average 6MWD in the TSC2-mutated group was 465.1 m versus 564.83 m in the TSC2-wildtype group (Student’s t-test, p = 0.0115). C The prevalence of pneumothorax in patients with a stop-gain TSC2 mutation was 87.5% (14/16) versus 44.8% (13/29) in patients with other mutation types (Chi-squared test, p = 0.0098). DLCO %pred = diffusing capacity of carbon monoxide percent predicted; 6MWD = six-minute walk distance. * indicates p < 0.05, ** indicates p < 0.01