Table 1 Baseline characteristics based on the MPV cutoff value
Characteristics | MPV > 11.4 fl (n = 60) | MPV ≤ 11.4 fl (n = 214) | P |
|---|---|---|---|
Age, year (mean ± SD) | 72.75 ± 11.24 | 70.77 ± 13.52 | 0.300 |
Male, n (%) | 37 (61.67) | 123 (53.02) | 0.561 |
BMI, kg/m2 (mean ± SD) | 24.02 ± 3.42 | 24.31 ± 4.71 | 0.597 |
APACHE II score, (mean ± SD) | 21.02 ± 6.67 | 18.44 ± 6.96 | 0.007 |
IMV duration, days (median, 25th–75th percentiles) | 7 (4–16) | 4 (1–9.25) | 0.053 |
ICU LOS, days (median, 25th–75th percentiles) | 17 (10–32) | 10 (3–20) | 0.000 |
H LOS, days (median, 25th–75th percentiles) | 21 (15.25–40.75) | 19 (13–28) | 0.069 |
Cause of mechanical ventilation, n (%) | |||
Exacerbation of chronic respiratory disorders | 15 (25) | 37 (17.29) | 0.178 |
Pneumonia | 18 (30) | 62 (28.97) | 0.887 |
Sepsis | 12 (20) | 43 (20.09) | 0.987 |
Postoperation | 8 (13.33) | 52 (24.30) | 0.070 |
Congestive heart failure | 4 (6.67) | 3 (1.40) | 0.040 |
Neurological disease | 2 (3.33) | 12 (5.61) | 0.741 |
others | 1 (1.67) | 5 (2.34) | 1.000 |
Comorbidity disease, n (%) | |||
Hypertension | 36 (60) | 114 (53.27) | 0.335 |
Diabetes Mellitus | 23 (38.33) | 54 (25.23) | 0.050 |
Chronic heart disorders | 21 (35) | 64 (29.9) | 0.451 |
Chronic respiratory disorders | 19 (31.67) | 61 (28.5) | 0.634 |
Malignancy | 14 (23.33) | 49 (22.90) | 0.943 |
Chronic kidney disease | 11 (18.33) | 22 (10.28) | 0.090 |
Cerebrovascular disease | 10 (16.67) | 33 (15.42) | 0.815 |
Immunosuppression | 3 (5) | 1 (0.46) | 0.034 |
Clinical outcome, n (%) | |||
Septic shock | 25 (41.67) | 41 (19.16) | 0.000 |
Acute renal injury | 29 (48.33) | 41 (19.16) | 0.000 |
Gastrointestinal bleeding | 18 (30) | 36 (16.82) | 0.023 |
Acute liver dysfunction | 26 (43.33) | 61 (28.50) | 0.029 |
Acute coronary syndrome | 8 (13.33) | 12 (5.61) | 0.042 |
Acute cerebrovascular disease | 3 (5) | 8 (3.74) | 0.710 |
Vasopressor use | 19 (31.67) | 39 (18.22) | 0.024 |
CRRT | 3 (5) | 11 (5.14) | 1.000 |
Sedation | 46 (76.67) | 146 (68.22) | 0.207 |
Hospital mortality | 28 (46.67) | 14 (6.54) | 0.000 |
Laboratory findings | |||
RR, breaths/min | 21.10 ± 5.252 | 19.83 ± 4.712 | 0.074 |
SpO2, % | 98 (96.25–100) | 99 (97.75–100) | 0.057 |
HR, beats/min | 87.70 ± 15.358 | 87.44 ± 14.794 | 0.907 |
SPB, mmHg | 130.38 ± 18.94 | 129.50 ± 21.98 | 0.778 |
PH | 7.45 (7.42–7.48) | 7.45 (7.42–7.48) | 0.718 |
PaCO2, mmHg | 54.5 (45.95–71) | 50 (44.3–60.7) | 0.054 |
PaO2, mmHg | 89 (78.65–95) | 89 (80–101.5) | 0.148 |
PaO2/FiO2, mmHg | 153.87 (130.26–172.86) | 161.82 (138.33–187.38) | 0.035 |
Lactate, mmol/L | 1.6 (1.2–2.5) | 1.3 (1.00–1.7) | 0.002 |
Hemoglobin, g/L | 93.13 ± 24.90 | 99.10 ± 21.73 | 0.070 |
Albumin, g/L | 26.08 ± 6.12 | 27.53 ± 6.65 | 0.130 |
Creatinine | 88.85 (55.43–125.30) | 74 (57.4–117.3) | 0.363 |
ALT, IU/L | 23 (16.63–32.5) | 19.15 (13–34.65) | 0.100 |
AST, IU/L | 32.55 (21.18–53.75) | 26.9 (18.5–43.05) | 0.095 |
Leukocyte count, × 109/L | 10.25 (8.25–12.05) | 9.7 (6.9–12.65) | 0.546 |
Neutrophils count, × 109/L | 7.52 (5.82–9.84) | 8.29 (5.8–11.74) | 0.380 |
Lymphocyte count, × 109/L | 0.73 (0.5–1.07) | 0.79 (0.53–1.29) | 0.303 |
Platelet count, × 109/L | 148 (107.5–202.75) | 184 (134.75–254.5) | 0.003 |
PDW, % | 14.45 (11.53–16.48) | 12 (10.5–12.925) | 0.000 |
Platelet large cell ratio, % | 34.02 ± 9.90 | 27.44 ± 7.74 | 0.000 |
CRP, mg/L | 70.5 (34.5–109.5) | 44.5 (18.75–84.0) | 0.002 |