Table 2 Demographic and clinical characteristics of 2,029 patients with NSCLC
Characteristic | Patients (n, %) | Without anemia (n, %) | With anemia (n, %) | P value |
|---|---|---|---|---|
Sex | 0.024 | |||
Male | 914 (45.0) | 667 (43.6) | 247 (49.4) | |
Female | 1115 (55.0) | 862 (56.4) | 253 (50.6) | |
Age (years) | 0.316 | |||
≤ 65 | 1408 (69.4) | 1070 (70.0) | 338 (67.6) | |
> 65 | 621 (30.6) | 459 (30.0) | 162 (32.4) | |
ECOG PS | 0.113 | |||
0–1 | 1569 (77.3) | 1190 (77.8) | 379 (75.8) | |
2 | 351 (17.3) | 252 (16.5) | 99 (19.8) | |
Unknown | 109 (5.4) | 87 (5.7) | 22 (4.4) | |
Smoking history | 0.074 | |||
No | 1313 (64.7) | 1006 (65.8) | 307 (61.4) | |
Yes | 716 (35.3) | 523 (34.2) | 193 (38.6) | |
Pathological type | 0.074 | |||
Adenocarcinoma | 1839 (90.6) | 1400 (91.6) | 439 (87.8) | |
Squamous cell carcinoma | 178 (8.8) | 122 (8.0) | 56 (11.2) | |
Large cell carcinoma | 7 (0.3) | 4 (0.3) | 3 (0.6) | |
Adenosquamous carcinoma | 5 (0.2) | 3 (0.2) | 2 (0.4) | |
EGFR mutation subtype | 0.014 | |||
Exon 19 deletion | 916 (45.1) | 639 (45.3) | 223 (44.6) | |
L858R | 891 (43.9) | 686 (44.9) | 205 (41.0) | |
Other | 222 (10.9) | 150 (9.8) | 72 (14.4) | |
Brain metastasis | 0.535 | |||
No | 1350 (66.5) | 1023 (66.9) | 327 (65.4) | |
Yes | 679 (33.5) | 506 (33.1) | 173 (34.6) | |
Bone metastasis | 0.034 | |||
No | 972 (47.9) | 753 (49.2) | 219 (43.8) | |
Yes | 1057 (52.1) | 776 (50.8) | 281 (56.2) | |
Surgical history | 0.092 | |||
No | 1225 (80.1) | 383 (76.6) | 1608 (79.3) | |
Yes | 304 (19.9) | 117 (23.4) | 421 (20.7) | |
Radiotherapy | 0.016 | |||
No | 1273 (62.7) | 928 (64.2) | 291 (58.2) | |
Yes | 756 (37.3) | 547 (35.8) | 209 (41.8) | |
Chemotherapy | < 0.001 | |||
No | 799 (39.4) | 676 (44.2) | 123 (24.6) | |
Yes | 1230 (60.6) | 853 (55.8) | 377 (75.4) | |
EGFR-TKI | 0.331 | |||
Gefitinib | 709 (34.9) | 552 (36.1) | 157 (31.4) | |
Erlotinib | 31 (1.5) | 24 (1.6) | 7 (1.4) | |
Icotinib | 1234 (60.8) | 915 (59.8) | 319 (63.8) | |
Afatinib | 36 (1.8) | 25 (1.6) | 11 (2.2) | |
Osimertinib | 19 (0.9) | 13 (0.9) | 6 (1.2) | |
CRP elevated | 0.638 | |||
No | 1188 (58.6) | 900 (58.9) | 288 (57.6) | |
Yes | 841 (41.4) | 629 (41.1) | 212 (42.4) | |
Grade of anemia | < 0.001 | |||
< 2 | 1857 (8.4) | 1529 (100) | 328 (65.6) | |
≥ 2 | 172 (24.6) | 0 (0.0) | 172 (34.4) | |