Table 3 Univariate and Multivariate Analyses of Clinical Parameters on PFS
Factor | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
HR (95% CI) | P Value | HR (95% CI) | P Value | |
Age, year (< 65 vs. ≥ 65) | 1.217 (0.813, 1.821) | 0.340 | —— | —— |
Gender (female vs. male) | 1.077 (0.689, 1.683) | 0.745 | —— | —— |
Smoking (never vs. smoker) | 0.685 (0.463, 1.102) | 0.058 | —— | —— |
Family History(yes vs no) | 1.012 (0.584, 1.703) | 0.966 | —— | —— |
Family History (yes vs no) | 1.858 (1.251, 2.760) | 0.002 | 2.719(1.786, 4.159) | < 0.001 |
ECOG PS (< 2 vs ≥ 2) | 1.323 (1.105,1.725) | 0.038 | 1.509(1.160, 1.946) | 0.002 |
Histology (NSCLC vs SCLC) | 2.348 (1.139, 4.840) | 0.021 | 2.713(1.035, 4.563) | 0.040 |
Neoplasm staging(III vs IV) | 1.738 (1.111, 2.720) | 0.015 | 1.238(0.770, 1.992) | 0.378 |
No. of treatment line (1 vs ≥ 2) | 0.828 (0.453, 1.514) | 0.539 | —— | —— |
Treatment regimen (combination vs. monotherapy) | 1.181 (0.817,1.708) | 0.377 | —— | —— |
OA treated (yes vs no) | 4.141 (2.715, 6.317) | < 0.001 | 4.994(3.217, 7.753) | < 0.001 |