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Table 2 Outcome of IPFT and surgical intervention

From: Retrospective review comparing intrapleural fibrinolytic therapy (alteplase) and surgical intervention in complex pleural effusion

Outcome

IPFT (n = 40)

Surgical intervention (n = 18)

p-value

Baseline chest radiography (cm2)—mean

119.96 ± 56.05

78.19 ± 55.6

0.026

Duration from baseline chest radiography to intervention (days)—median (IQR)

2.0 (1–11)

3.5 (1–32)

0.12

Week 1a

Chest radiograph changes (%)—mean

31.68 ± 36.37

32.05 ± 33.24

0.976

Success rate (n)

8 (27%)

2 (20%)

1.000

Week 4–8b

Chest radiograph changes (%)- median (IQR)

49.8 (− 123.48–100)

73.46 (45.79–100)

0.054

Success rate (n)

15 (56%)

8 (80%)

0.26

Pre-intervention total white cells (× 109/L)–median (IQR)

10.4 (4.1–60.4)

9.75 (6.9–18.8)

0.545

48 h post-intervention total white cells (× 109/L)—median (IQR)

12.15 (5.4–84.8)

11.1 (4.5–22.8)

0.656

pre-intervention CRP (mg/dL)—median (IQR)

9.64 (0.48–33.2)

9.48 (0.48–43.59)

0.808

48 h post-intervention CRP (mg/dL)—median (IQR)

10.41 (0.77–25.45)

6.41 (2.58–31.84)

0.664

Duration of a chest tube in situ (days)—median (IQR)

14 (3–193)

13.5 (8.5–19.75)

0.686

Length of stay (days)—median (IQR)

21.5 (3–73)

26.5 (7–68)

0.068

Mortality at 30 days (n)

2 (5%)

0 (0%)

0.587

Immediate post-intervention complicationsc (n)

11 (27.5%)

17 (94%)

 < 0.0005

 Hypotension

0

16

 Bleeding

2

1

 Fever

6

0

 Chest pain

3

0

  1. aMissing data: 9 from intrapleural alteplase and 8 from surgical intervention at week 1 (4 pneumonectomies, 1 lobectomy)
  2. bMissing data: 11 from intrapleural alteplase and 8 from surgical intervention at weeks 4–8 (4 pneumonectomies, 1 lobectomy)
  3. cImmediate post-intervention complications: fever, chest pain, bleeding, hypotension