Table 1 General characteristics of the study population
All cohort n = 156 | BAD at Day 90 n = 42 (27) | No BAD at Day 90 n = 114 (73) | p | |
|---|---|---|---|---|
Preoperative characteristics | ||||
Male sex, n (%) | 102 (65) | 30 (71) | 72 (63) | 0.45 |
Age, median [IQR] | 56 [50–62] | 57 [51–60] | 56 [50–62] | 0.92 |
BMI, median [IQR] | 24 [20–27] | 24 [23–27] | 23 [20–26] | 0.08 |
Comorbidities, n (%) | ||||
HBP | 35 (22) | 10 (24) | 25 (22) | 0.83 |
Diabetes mellitus | 14 (9) | 6 (14) | 8 (7) | 0.20 |
Dyslipidaemia | 41 (26) | 13 (31) | 28 (25) | 0.42 |
Ischaemic heart disease | 11 (7) | 1 (2) | 10 (9) | 0,29 |
Peripheral artery occlusive disease | 10 (7) | 3 (7) | 7 (6) | 1.00 |
Pulmonary hypertension | 81 (54) | 20 (50) | 61 (55) | 0.71 |
Right ventricle dilatation before LT | 42 (27) | 13 (31) | 29 (25) | 0.54 |
Underlying disease, n (%) | ||||
COPD | 55 (35) | 13 (31) | 42 (37) | 0.57 |
PF | 64 (41) | 18 (43) | 46 (41) | 0.86 |
Other | 37 (24) | 11 (26) | 26 (23) | 0.68 |
Need for MV before surgery, n (%) | 6 (4) | 2 (5) | 4 (3,5) | 0.66 |
High-emergency LT, n (%) | 26 (17) | 10 (24) | 16 (14) | 0.15 |
Retransplantation, n (%) | 4 (3) | 3 (7) | 1 (1) | 0.06 |
Procedure | ||||
Bilateral LT, n (%) | 107 (67) | 33 (79) | 74 (65) | 0.12 |
Postoperative variables | ||||
SOFA score on ICU admission, median [IQR] | 7 [5–8] | 7 [5–8, 5] | 6 [5–8] | 0.36 |
SAPS II score on ICU admission, median [IQR] | 36 [26–48] | 38 [28–52] | 36 [25–47] | 0.15 |
Neuromuscular blocking agent administration, n (%) | 46 (30) | 20 (48) | 26 (23) | 0.01 |
Prone positioning, n (%) | 18 (12) | 7 (17) | 11 (10) | 0.26 |
PGD, n (%) | 85 (55) | 24 (57) | 61 (54) | 0.72 |
Number of pneumonia, median [IQR] | 1 [1–2] | 2 [1–3] | 1 [1–1] | 0.001 |
Acute cellular rejection, n (%) | 21 (14) | 7 (17) | 14 (12) | 0.60 |
Antibody mediated rejection, n (%) | 44 (29) | 18 (43) | 26 (23) | 0.03 |
Surgical thoracic reintervention, n (%) | 22 (14) | 10 (24) | 12 (11) | 0.04 |
Abdominal surgery, n (%) | 16 (10) | 8 (19) | 8 (7) | 0.04 |
Tracheostomy for ventilation weaning, n (%) | 32 (21) | 19 (45) | 13 (12) | < 0.0001 |
Outcome | ||||
Duration of MV, median [IQR] | 3 [1–10, 5] | 7 [2–38] | 2 [1–5] | < 0.0001 |
Duration of hospitalization in ICU, median [IQR] | 14 [9–25] | 23 [12–56] | 13 [9–22] | 0.001 |
Death at Day 28, n (%) | 10 (6) | 2 (5) | 8 (7) | 1.00 |
Death at Day 90, n (%) | 24 (15) | 11(26) | 13 (11) | 0.04 |
Death at one year, n (%) | 38 (24) | 18 (43) | 20 (18) | 0.003 |