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Table 2 Haemodynamic status and BAD occurrence at Day 90, univariate analysis

From: ECMO support as a bridge to lung transplantation is an independent risk factor for bronchial anastomotic dehiscence

 

BAD at day 90

No BAD at day 90

p

n = 42 (27)

n = 114 (73)

Haemodynamic status before LT

Catecholamine administration to the donor, n (%)

32 (84)

90 (86)

0.79

Catecholamine > 0.5 γ/kg/min to the donor, n (%)

6 (14)

14 (12)

0.79

Cardiac arrest of the donor, n (%)

13 (31)

33 (29)

0.84

RBC transfusion of the donor, n (%)

14 (37)

30 (29)

0.41

ECMO as a bridge to LT (recipient), n (%)

6 (14)

3 (3)

0.01

Haemodynamic status during LT surgery

Catecholamine > 0.5 γ/kg/min during surgery, n (%)

13 (31)

37 (32)

1.00

ECMO support during surgery, n (%)

37 (88)

80 (70)

0.02

ECMO weaned in operating room, n (%)

21 (50)

56 (50)

1.00

Vascular filling > 30 mL/kg, n (%)

38 (91)

98 (88)

0.78

Vascular filling > 2500 mL, n (%)

38 (91)

100 (89)

1.00

RBC transfusion, n (%)

31 (74)

75 (66)

0.44

 > 5 RBC units transfusion, n (%)

9 (22)

23 (20)

0.83

FFP transfusion, n (%)

30 (71)

70 (61)

0.27

Platelet transfusion, n (%)

15 (40)

29 (27)

0.15

Cardiac arrest during surgery, n (%)

1 (2)

6 (5)

0.68

Haemodynamic status during hospitalization in ICU

Lactate on ICU admission > 2 mmol/l, n (%)

21 (50)

56 (49)

1.00

Lactate on ICU admission > 3 mmol/l, n (%)

9 (21)

29 (25)

0.68

Catecholamines administration during hospitalization in ICU, n (%)

38 (93)

107 (96)

0.39

Duration of catecholamine administration, days, median [IQR]

2 [1–3, 5]

1 [1–3]

0.16

Duration of ECMO support, days, median [IQR]

0 [0–3]

0 [0–1]

0.06

Atrial fibrillation, n (%)

18 (43)

28 (25)

0.05

AKI, n (%)

29 (69)

23 (20)

 < 0.0001

KDIGO stage, median [IQR]

1 {0–2]

1 [0–2]

0.16

RRT, n (%)

5 (12)

11 (10)

0.77

Septic shock, n (%)

18 (43)

19 (17)

0.001

Haemorrhagic shock, n (%)

4 (10)

13 (11)

1

Cardiogenic shock, n (%)

5 (12)

7 (6)

0.31

MOF syndrome, n (%)

17 (42)

26 (23)

0.03

Cardiac arrest during hospitalization in ICU, n (%)

7 (17)

10 (9)

0.16

  1. BAD bronchial anastomotic dehiscence, LT lung transplantation, RBC red blood cell, ECMO extracorporeal membrane oxygenation, FFP fresh frozen plasma, ICU intensive care unit, IQR interquartile range, acute kidney injury, KDIGO kidney disease improving global outcome, RRT, renal replacement therapy, MOF multiorgan organ failure