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Table 3 Univariate and multivariate Cox proportional hazards analyses

From: Postoperative survival of pulmonary invasive mucinous adenocarcinoma versus non-mucinous invasive adenocarcinoma

Variables

Univariate analysis

Multivariable analysis

HR

95% CI

p

HR

95% CI

p

Age (years)

≤ 66

Reference

     

> 65

1.59

1.53–1.65

< 0.0001

1.69

1.62–1.75

< 0.0001

Chemotherapy

No

Reference

     

Yes

1.49

1.44–1.55

< 0.0001

0.78

0.74–0.82

< 0.0001

Grade

I

Reference

     

II

1.64

1.55–1.73

< 0.0001

1.43

1.35–1.52

< 0.0001

III

2.22

2.1–2.36

< 0.0001

1.66

1.57–1.77

< 0.0001

IV

1.95

1.56–2.43

< 0.0001

1.43

1.15–1.79

0.0016

Unknown

1.44

1.31–1.59

< 0.0001

1.23

1.11–1.35

< 0.0001

IMA

No

Reference

     

Yes

0.78

0.66–0.91

0.001

1.03

0.87–1.2

0.7596

Laterality

Left

Reference

     

Right

0.97

0.94–1.01

0.113

   

Location

Upper

Reference

     

Lower

1.1

1.06–1.14

< 0.0001

1.12

1.07–1.16

< 0.0001

Middle

1.08

0.99–1.17

0.08

1.14

1.05–1.24

0.0019

Other

1.55

1.39–1.73

< 0.0001

1.23

1.1–1.37

0.0003

Marital status

Single

Reference

     

Divorced

0.93

0.88–0.99

0.016

0.99

0.94–1.05

0.8243

Married

0.85

0.81–0.88

< 0.0001

0.83

0.79–0.86

< 0.0001

N

N0

Reference

     

N1

2.11

2.01–2.21

< 0.0001

1.33

1.13–1.57

0.0007

N2

2.44

2.33–2.56

< 0.0001

1.29

0.92–1.81

0.143

N3

3.72

2.87–4.82

< 0.0001

1.88

1–3.55

0.05

Operation

Lobectomy

Reference

     

Lobectomy extended

1.46

1.34–1.58

< 0.0001

1.24

1.14–1.35

< 0.0001

Other sublobar

1.29

1.02–1.62

0.031

1.22

0.97–1.54

0.0873

Pneumonectomy

2

1.83–2.18

< 0.0001

1.25

1.14–1.37

< 0.0001

Segmentectomy

1.03

0.92–1.15

0.575

1.2

1.07–1.34

0.0017

Wedge

1.21

1.13–1.29

< 0.0001

1.39

1.3–1.49

< 0.0001

Race

Black

Reference

     

Other

0.77

0.7–0.84

< 0.0001

0.76

0.69–0.83

< 0.0001

White

1.02

0.95–1.08

0.636

1.03

0.96–1.1

0.4243

Radiation

No

Reference

     

Yes

1.96

1.87–2.06

< 0.0001

1.3

1.22–1.38

< 0.0001

Sex

Male

Reference

     

Female

0.69

0.67–0.72

< 0.0001

0.7

0.68–0.73

< 0.0001

Size

1.01

1.01–1.01

< 0.0001

1

1–1

0.0076

Stage

IA1

Reference

     

IA2

1.37

1. 22–1.54

< 0.0001

1.28

1.13–1.44

0.0001

IA3

1.87

1.67–2.11

< 0.0001

1.64

1.46–1.86

< 0.0001

IB

2.2

1.94–2.49

< 0.0001

1.71

1.48–1.97

< 0.0001

IIA

2.53

2.21–2.9

< 0.0001

1.91

1.64–2.24

< 0.0001

IIB

3.39

3.01–3.81

< 0.0001

2.43

1.97–3

< 0.0001

IIIA

4.18

3.71–4.7

< 0.0001

2.86

2–4.09

< 0.0001

IIIB

5.71

4.95–6.58

< 0.0001

3.49

1.97–6.18

< 0.0001

IIIC

5.18

2.98–9.03

< 0.0001

2.23

0.81–6.1

0.1186

T

T1

Reference

     

TT2

1.54

1.47–1.6

< 0.0001

1.11

1.03–1.19

0.0053

TT3

1.92

1.8–2.05

< 0.0001

0.96

0.79–1.17

0.7066

TT4

2.46

2.27–2.66

< 0.0001

1.08

0.8–1.45

0.6232

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