Fig. 3
From: Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinoma
Typical pathological pictures (100x) of case 1: adenocarcinoma in situ (AIS) A hematoxylin–eosin (HE) staining showed the lepidic growth of tumor cells with B PD-L1 (SP-28-8) staining negative (< 1%); case 2: Invasive adenocarcinoma (IAC) stage IA3 of solid dominant subtype C PD-L1 (SP-28-8) staining strongly positive (80%) and D spread through air space (STAS) of the solid nest (red arrow) beyond tumor edge