Table 2 PD-L1 positive rate in early-stage lung adenocarcinoma from AIS, MIA to IAC stage IA1–IA3
From: Expression of PD-L1 through evolution phase from pre-invasive to invasive lung adenocarcinoma
PDL1 (−) (%) | PD-L1≥1% | p value | PD-L1≥50% | p value | Total | ||||
|---|---|---|---|---|---|---|---|---|---|
AIS | 11 | 100.00 | 0 | 0.00 | < 0.001 | 0 | 0.00 | 0.012 | 11 |
MIA | 198 | 99.00 | 2 | 1.00 | 0 | 0.00 | 200 | ||
IA1 | 244 | 92.78 | 19 | 7.22 | 1 | 0.38 | 263 | ||
IA2 | 432 | 88.71 | 55 | 11.29 | 8 | 1.64 | 487 | ||
IA3 | 139 | 85.80 | 23 | 14.20 | 6 | 3.70 | 162 | ||
IA (Grade 1) | 20 | 86.96 | 3 | 13.04 | < 0.001 | 0 | 0.00 | < 0.001 | 23 |
IA (Grade 2) | 739 | 91.23 | 71 | 8.77 | 9 | 1.11 | 810 | ||
IA (Grade 3) | 56 | 70.89 | 23 | 29.11 | 6 | 7.59 | 79 | ||
Lepidic dominant | 83 | 92.22 | 7 | 7.78 | < 0.001 | 0 | 0.00 | < 0.001 | 90 |
Acinar dominant | 660 | 90.91 | 66 | 9.09 | 7 | 0.96 | 726 | ||
Papillary dominant | 36 | 92.31 | 3 | 7.69 | 0 | 0.00 | 39 | ||
Micropapillary dominant | 3 | 60.00 | 2 | 40.00 | 0 | 0.00 | 5 | ||
Solid dominant | 10 | 45.45 | 12 | 54.55 | 5 | 22.73 | 22 | ||
Invasive mucinous | 25 | 89.29 | 3 | 10.71 | 1 | 3.57 | 28 | ||
STAS(+) | 37 | 75.51 | 12 | 24.49 | < 0.001 | 3 | 6.12 | 0.017 | 49 |
STAS(-) | 987 | 91.90 | 87 | 8.10 | 12 | 1.12 | 1074 | ||
Vascular invasion (+) | 12 | 66.67 | 6 | 33.33 | < 0.001 | 3 | 16.67 | 0.001 | 18 |
Vascular invasion (-) | 1012 | 91.58 | 93 | 8.42 | 12 | 1.09 | 1105 | ||
Lymphatic invasion (+) | 1 | 100.00 | 0 | 0.00 | N/A | 0 | 0.00 | N/A | 1 |
Lymphatic invasion (-) | 1023 | 91.10 | 99 | 9.68 | 15 | 1.46 | 1122 | ||