Table 3 Prognostic factors for median overall survival in LCC patients with SBM

Year of diagnosis

2010–2014

Reference

–

2015–2019

0.8 (0.58–1.1)

0.168

Age

 < 60

Reference

–

Reference

–

60–79

1.63 (1.22–2.19)

0.001

1.55 (1.14, 2.10)

0.005

 ≥ 80

1.17 (0.62–2.21)

0.622

0.71 (0.36, 1.38)

0.311

Sex

Male

Reference

–

Female

0.97 (0.73–1.28)

0.816

Race

White

Reference

–

Black

0.75 (0.5–1.13)

0.174

Other

0.63 (0.32–1.24)

0.183

Marital status

Married

Reference

–

Single

0.97 (0.73–1.28)

0.833

Median household income

 < $55,000

Reference

–

$55,000–$74,999

0.94 (0.69–1.27)

0.676

$75,000+

0.93 (0.6–1.44)

0.736

Primary site

Main bronchus

Reference

–

Upper lobe

0.83 (0.42–1.64)

0.596

Middle lobe

1.04 (0.35–3.11)

0.943

Lower lobe

1.05 (0.52–2.15)

0.885

Unspecific

0.89 (0.4–1.96)

0.765

Laterality

Left

Reference

–

Right

0.97 (0.74–1.29)

0.855

Bilateral

2.1 (0.66–6.69)

0.207

Grade

III

Reference

–

IV

0.9 (0.62–1.3)

0.562

Unknown

1 (0.72–1.4)

0.986

T stage

T1

Reference

–

Reference

–

T2

0.84 (0.5–1.39)

0.495

0.99 (0.58, 1.69)

0.973

T3

1.52 (0.93–2.48)

0.095

2.31 (1.36, 3.92)

0.002

T4

1.46 (0.93–2.31)

0.103

1.62 (0.99, 2.65)

0.056

T0

12.18 (2.78–53.36)

0.001

29.95 (6.57, 136.51)

 < 0.001

N stage

N0

Reference

–

N1

0.81 (0.49–1.35)

0.415

N2

1.28 (0.92–1.8)

0.145

N3

1.19 (0.77–1.83)

0.442

Bone metastases

No

Reference

–

Reference

–

Yes

1.57 (1.17–2.11)

0.003

1.81 (1.30, 2.50)

 < 0.001

Liver metastases

No

Reference

–

Reference

–

Yes

1.57 (1.1–2.23)

0.013

1.06 (0.73, 1.55)

0.743

Lung metastases

No

Reference

–

Yes

1.07 (0.75–1.53)

0.718

Surgery for primary site

No

Reference

Reference

–

Yes

0.57 (0.29–1.11)

0.1

0.55 (0.27, 1.12)

0.099

Chemotherapy

No

Reference

Reference

–

Yes

0.31 (0.23–0.41)

 < 0.001

0.26 (0.19, 0.36)

 < 0.001

Radiation

No

Reference

Reference

–

Yes

0.56 (0.4–0.78)

0.001

0.78 (0.54, 1.11)

0.166