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Table 3 Independent mortality predictors: specific comorbidities and clinical presentation (n = 3663)

From: Developing a mortality risk prediction model using data of 3663 hospitalized COVID-19 patients: a retrospective cohort study in an Egyptian University Hospital

 

Mortality incidence

Adjusted HR (95% CI)a

P-value

Adjusted HR (95% CI)a

P-value

% (deaths/total)

Model 1b

Model 2c

Specific comorbidities

Hypertension

34.5 (364/1055)

1.24 (1.09–1.42)

0.001

1.09 (0.91–1.30)

0.347

Diabetes

32.1 (321/999)

1.14 (1.0–1.31)

0.055

0.94 (0.78–1.12)

0.476

Heart disease (other than ischemic)

47.1 (101/213)

1.44 (1.17–1.78)

0.001

0.98 (0.78–1.24)

0.879

Obesity

41.8 (81/194)

1.60 (1.28–2.01)

 < 0.001

1.39 (1.08–1.79)

0.011

Ischemic heart disease

38.5 (60/156)

1.37 (1.05–1.78)

0.019

1.21 (0.92–1.58)

0.169

Chronic kidney disease

46 (58/126)

1.49 (1.14–1.96)

0.004

1.03 (0.78–1.36)

0.829

Cerebrovascular disease

48.7 (57/117)

1.47 (1.13–1.93)

0.005

0.99 (0.74–1.31)

0.923

Chronic liver disease

54.7 (47/86)

1.51 (1.12–2.03)

0.007

0.84 (0.62–1.13)

0.25

Malignancy

56.6 (43/76)

2.37 (1.72–3.25)

 < 0.001

1.84 (1.33–2.53)

 < 0.001

Chronic obstructive pulmonary disease

44.6 (33/74)

1.91 (1.35–2.71)

 < 0.001

1.24 (0.86–1.77)

0.251

Surgery

40.7 (24/59)

1.76 (1.17–2.66)

0.007

1.12 (0.73–1.70)

0.611

Other lung diseases

41.1 (23/56)

1.85 (1.22–2.80)

0.004

1.04 (0.68–1.59)

0.855

Chronic hematological disease

41.2 (21/51)

2.31 (1.50–3.57)

 < 0.001

1.68 (1.08–2.61)

0.022

Immunological disorder

33.3 (14/42)

1.86 (1.09–3.15)

0.022

1.64 (0.86–3.13)

0.133

Transplant recipients

40.9 (9/22)

1.85 (0.96–3.57)

0.068

1.54 (0.63–3.78)

0.348

Pregnancy

50.0 (5/10)

1.36 (0.56–3.28)

0.499

0.50 (0.17–1.44)

0.201

Specific symptoms/presentationd

Dyspnea

30.5 (399/1307)

1.32 (1.16–1.51)

 < 0.001

3.73 (2.97–4.68)

 < 0.001

Distress/Hypoxia

44.2 (559/1265)

2.14 (1.88–2.43)

 < 0.001

3.65 (2.90–4.60)

 < 0.001

Diarrhea

42.7 (177/415)

1.49 (1.26–1.75)

 < 0.001

1.00 (0.84–1.19)

0.987

  1. HR Hazard ratio, CI Confidence interval
  2. Bold indicates statistical significance
  3. aMultivariable Cox proportional hazard regression was used
  4. bModel 1: Each comorbidity or symptom was separately corrected by age, gender, and smoking status
  5. cModel 2: As Model-1 with further correction by the condition on admission, and the presence of other comorbidities or symptoms
  6. dVariables included were those with P-value < 0.05 on bivariate analysis
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BMC Pulmonary Medicine

ISSN: 1471-2466

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