Fig. 1

Avitinib reduced bleomycin-induced pulmonary fibrosis in C57BL/6 J mice. The mice were intratracheally treated bleomycin (2U/kg) on day 0, AVB (15, 30 and 60 mg/kg) and Nin (100 mg/kg) were administrated orally from days 7– 13, lungs of mice were harvested on day 14. A Structure of Avitinib (The structural formula is quoted from Pubchem). B Hydroxyproline contents in right lung tissues. C Quantitative analysis of fibrotic area in left lung tissues. D-G Pulmonary function tests, including forced vital capacity (FVC), dynamic compliance (Cydn), expiratory resistance (Re) and inspiratory resistance (Ri). H Hematoxylin–eosin (H&E) staining of left lung tissue sections for tissue structures and Masson staining was used to analyze the collagen contents in left lung sections. Scale bars:50 µM. Data was noted as the means ± SD, n = 6. ^####P < 0.0001 versus NaCl group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 versus BLM group