Fig. 5

Avitinib improves alveolar epithelial cell injury in A549 cells. A AVB significantly inhibited TGF-β1-induced morphological changes in A549 cells. Scale bars: 100 μM. B-C AVB (1.25, 2.5 µM) and/or TGF- β1 (5 ng/mL) was exposed to A549 cells for 24 h, and quantitative real-time PCR was used to analyze the mRNA transcription level of E-cadherin and Vimentin. D-F TGF-β1 (5 ng/mL) and/or AVB (1.25,2.5 µM) were exposed to A549 cells for 25 h, and the E-cadherin and Vimentin expression levels were detected by Western Blot. Quantitative analyses of Western blot are shown beside. Data was presented as the means ± SD, n = 3. ^##P < 0.01, ^###P < 0.001, ^####P < 0.0001 versus control group. *P < 0.05, **P < 0.01, ***P < 0.001 versus TGF-β1 group