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Table 2 Recommendations adopted with minor changes and those added to the clinical referral pathway for Primary Care Management of Bronchiectasis

From: GRADE-ADOLOPMENT of clinical practice guidelines and creation of clinical pathways for the primary care management of chronic respiratory conditions in Pakistan

Recommendations adopted with Minor Changes

Original Recommendations

Recommendations Adopted with Minor Changes

“For P. aeruginosa colonised patients

Consider azithromycin or erythromycin as an alternative (eg, if a patient does not tolerate inhaled antibiotics) to an inhaled antibiotic for patients with bronchiectasis and chronic P. aeruginosa infection. (B)” [27]

For P. aeruginosa colonised patients

Consider azithromycin as an alternative (e.g., if a patient does not tolerate inhaled antibiotics) to an inhaled antibiotic for patients with bronchiectasis and chronic P. aeruginosa infection. (B)

“For P. aeruginosa colonised patients

Consider azithromycin or erythromycin as an additive treatment to an inhaled antibiotic for patients with bronchiectasis and chronic P. aeruginosa infection who have a high exacerbation frequency. (D)” [27]

For P. aeruginosa colonised patients

Consider azithromycin as an additive treatment to an inhaled antibiotic for patients with bronchiectasis and chronic P. aeruginosa infection who have a high exacerbation frequency. (D)

“For non-P. aeruginosa colonised patients

Use azithromycin or erythromycin for patients with bronchiectasis. (A)” [27]

For non-P. aeruginosa colonised patients

Use azithromycin for patients with bronchiectasis. (A)

“For non-P. aeruginosa colonised patients

Consider inhaled gentamicin as a second line alternative to azithromycin or erythromycin. (B)” [27]

For non-P. aeruginosa colonised patients

Consider inhaled gentamicin as a second line alternative to azithromycin. (B)

Added Recommendation

Source

“Look for signs and symptoms (chronic productive cough with purulent or mucopurulent sputum, recurrent chest infections and shortness of breath) that raise suspicion towards a diagnosis of bronchiectasis”

Medscape [39, 40]

“Assess risk factors – modifiable (smoking) and non-modifiable (pre-existing conditions like cystic fibrosis, immunodeficiency disorders, connective tissue disorders, ABPA and recent severe pneumonia) – for bronchiectasis”

NIH National Heart, Lung and Blood Institute [41]

“For adult patients with no suspicious signs and symptoms aligning with bronchiectasis, but with significant risk factors towards developing it, offer counselling regarding the modifiable risk factors, in this case - smoking. Recommend cessation of smoking and avoiding inhaling secondhand smoke, if applicable.”

Medscape [39, 42]

ABPA: Allergic Bronchopulmonary Aspergillosis. NIH: National Institutes of Health