In-hospital antibiotic use for severe chronic obstructive pulmonary disease exacerbations: a retrospective observational study

Table 4 Cox regression analysis of antibiotic treatment on risk of in-hospital mortality

	Total	Model 1 HR [95% CI], p-value	Model 2 HR [95% CI], p-value	Model 3 HR [95% CI], p-value
Main analysis		n events/total = 25/431	n events/total = 18/354	n events/total = 16/208
No in-hospital AB	138	Reference	Reference	Reference
In-hospital AB (all)	293	0.72 [0.30; 1.75], p = 0.470	0.64 [0.19; 2.17], p = 0.474	0.34 [0.08; 1.45], p = 0.145

Abbreviations: AB antibiotics, CI confidence interval, HR hazard ratio
Model 1 is adjusted for age
Model 2 is additionally adjusted for C-reactive protein, chronic kidney disease, body mass index, diabetes, pH, cancer, heart failure, sputum purulence and respiratory failure
Model 3 is additionally adjusted for forced expiratory volume in 1 s % predicted

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