Fig. 3

Performance of PAH risk assessment tools. The Elastic Net signature was developed as presented in Fig. 2. The ensemble of the established risk assessment tools (FPHR 3p: French Pulmonary Hypertension Registry 3 parameter score, FPHR 4p: French Pulmonary Hypertension Registry 4 parameter score, COMPERA: Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension score, mRASP: modified Risk Assessment Score of PAH) was developed by Ridge Cox regression as presented in Supplementary Figure S3. Predictive performance of the Elastic Net signature, ensemble and single PAH risk scores at predicting overall survival was assessed by concordance index (C-index) and integrated Brier score (IBS). C-indexes and IBS for the risk assessment tools in the Innsbruck (IBK) and Linz/Vienna (LZ/W) cohorts are displayed in scatter plots, point size and color codes for \({R}^{2}\)