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Table 3 LungLBâ„¢ Test Performance by Participant Characteristic

From: The presence of circulating genetically abnormal cells in blood predicts risk of lung cancer in individuals with indeterminate pulmonary nodules

Category

n

AUC

Sensitivity

(%)

Specificity

(%)

All Samples (Mayo Clinic Model)

151

0.5182

23.4

89.7

Samples with Available PET Scan

79

0.5674

67.2

.4

All Samples (Unweighted)

151

0.7379

67.9

74.4

All Samples (Weighted for Advanced CGACs)

151

0.7834

76.8

71.8

 Nodule Size

    

  < 2 cm

83

0.8269

83.9

69.5

  ≥ 2 cm

68

0.7049

69.1

69.2

 Nodule Consistency

    

  Solid

92

0.7215

65.2

65.2

  Subsolid

41

0.8952

83.3

80.0

 Cancer Stage

    

  I

76

0.7945

79.0

74.4

  II-IV

31

0.6716

61.3

71.8

  Unknown

5

0.7333

80.0

71.8

 Malignant Lesion Type

    

  Adenocarcinoma

73

0.7875

72.6

74.4

  Squamous Cell Carcinoma

17

0.8250

88.2

71.8

  Small Cell and Neuroendocrine

17

0.7541

76.5

71.8

  Other

5

0.6970

60.0

69.2

 Smoking History

    

 Ever

120

0.7929

76.4

71.0

 Never

30

0.8075

78.3

85.7

  1. Abbreviations: AUC, area under the curve, CGAC, circulating genetically abnormal cell, PET, positron emission tomography. Results from all 39 benign nodules were used as the comparator for cancer stage and malignant lesion type