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Table 1 General characteristics of the population

From: Prevalence of genetic mutations in alpha-1 antitrypsin deficiency (aatd) in patients with chronic obstructive pulmonary disease in Colombia

Variables

No mutation

n = 963

Mutation

n = 144

Total

n = 1,107

p-value

Male, n (%)

602 (62.1)

91 (63.2)

693 (62.6)

0.875

Age, median (p25-p75)

73.8

(67.6–79.9)

73

(66.6–79.9)

73.8

(67.4–79.9)

0.428

Weight, median (p25-p75)

65

(56–74)

65

(56.5–75)

65

(56–74)

0.468

BMI, median (p25-p75)

25.1

(22.1–28.7)

25.2

(22.8–28.5)

25.1

(22.2–28.6)

0.410

Age at onset of symptoms, median (p25-p75)

64

(55–70)

63

(55–70)

64

(55–70)

0.971

Age at diagnosis, median (p25-p75)

65

(58–72)

65

(59–72)

65

(58–72)

0.972

Moderate exacerbations in the previous year, mean ± SD

0.25 ± 0.65

0.20 ± 0.66

0.24 ± 0.65

0.424

Severe exacerbations in the previous year, mean ± SD

0.09 ± 0.35

0.11 ± 0.28

0.10 ± 0.35

0.514

Comorbidities and exposure factors

HT, n (%)

521 (54.1)

78 (54.2)

599 (54.1)

0.988

Diabetes mellitus, n (%)

119 (13.4)

21 (14.6)

140 (12.6)

0.453

Heart failure, n (%)

169 (17.5)

18 (13.5)

187 (16.9)

0.131

Smoking, n (%)

691 (71.7)

108 (75)

799 (72.2)

0.418

Years smoking, median

(p25-p75)

38

(24–47)

35

(20–45)

38

(22–47)

0.283

PY, median (p25-p75)

30 (15–50)

25 (10-49.5)

30 (15–50)

0.119

 s-hand smoke, n (%)

189 (19.6)

25 (17.4)

214 (19.3)

0.517

Biomass, n (%)

297 (30.8)

34 (23.6)

331 (29.9)

0.077

Biomass index, median

(p25-p75)

90

(40–200)

85

(60–160)

90

(40–200)

0.858

Tuberculosis, n (%)

51 (5.3)

12 (8.33)

63 (5.7)

0.142

Occupational smoke, n (%)

117 (13.6)

15 (10.9)

132 (13.2)

0.386

  1. BMI: body mass index; HT: hypertension, PY: pack-years, P: differences between subjects with and without the mutation. Values as mean ± standard deviation or median (p25-p75) or n (%)