Fig. 4

ILC2 depletion inhibited Th17 cell response. A Newborn mice were treated with anti-CD90.2 antibody or control IgG twice during hyperoxia exposure. Neonatal mice in different groups were sacrificed at day 14. B Representative results and the percentage of ILC2 detected by flow cytometry in the lungs of the hyperoxia, hyperoxia + control IgG, and hyperoxia + anti-CD90.2 groups. C Representative results and percentage of Th17 cells detected by flow cytometry in lung samples of the hyperoxia, hyperoxia + control IgG, and hyperoxia + anti-CD90.2 groups. D–G IL-6, IL-17 A, IL-17 F, and IL-22 levels in the blood serum and lung tissues were assessed in the hyperoxia, hyperoxia + control IgG, and hyperoxia + anti-CD90.2 groups. Data presented are the mean ± SD (n = 6); ** P < 0.05 vs. hyperoxia group