The PaO2/FiO2 is independently associated with 28-day mortality in patients with sepsis: a retrospective analysis from MIMIC-IV database

Table 2 Relationship between LnPaO₂/FiO₂ and 28-day mortality in patients with sepsis

Exposure	Non-adjusted (OR, 95%CI, p)	Adjust I (OR, 95%CI, p)	Adjust II (OR, 95%CI, p)
LnPaO₂/FiO₂	0.49 (0.46, 0.52) < 0.0001	0.49 (0.46, 0.52) < 0.0001	0.72 (0.67,0.79) < 0.0001
LnPaO₂/FiO₂(quartile)
Q1	Ref	Ref	Ref
Q2	0.51 (0.46, 0.56) < 0.0001	0.50 (0.45, 0.55) < 0.0001	0.60 (0.53, 0.67) < 0.0001
Q3	0.43 (0.38, 0.47) < 0.0001	0.41 (0.37, 0.46) < 0.0001	0.66 (0.59, 0.75) < 0.0001
Q4	0.44 (0.39, 0.48) < 0.0001	0.44 (0.40, 0.49) < 0.0001	0.82 (0.72, 0.93) 0.0017
P for trend	< 0.0001	< 0.0001	0.0005
Chi-square / P for H–L Test	81.033 / < 0.001	37.862 / < 0.001	20.337 / 0.009

Non-adjusted model adjusted for: None
Adjust I model adjusted for: sex, age at admission, ethnicity
Adjust II model adjusted for: sex, age at admission, ethnicity, Charlson Comorbidity Index, SOFA scores, the use of dexamethasone, methylprednisolone, cortisone, noradrenaline, dopamine, dobutamine, IVIG, the use of mechanical ventilation and RRT, the use of carbapenem, cephalosporins, penicillin, vancomycin, heart rate, respiratory rate, temperature and MAP
OR Odds ratio, CI Confidence interval, Ref Rreference, H–L Test Hosmer Lemeshow Test

ISSN: 1471-2466