Assessing the genetic relationship between gastroesophageal reflux disease and chronic respiratory diseases: a mendelian randomization study

Table 2 Estimates of sensitivity analyses of GERD and 5 chronic respiratory diseases

Outcomes	MR-PRESSO			Weighted median method		MR-Egger
Outcomes	OR (95%CI)	P-value	Outlier number	OR (95%CI)	P-value	OR (95%CI)	P-value	P_intercept
Asthma	1.46(1.33–1.59)^*	< 0.001^*	2	1.36(1.23–1.51)	< 0.001	0.91(0.62–1.33)	0.63	0.026
IPF	1.50(1.14–1.99)	0.01	0	1.27(0.84–1.93)	0.25	4.40(1.57–12.34)	0.01	0.030
COPD	1.62(1.41–1.87)^*	< 0.001^*	1	1.44(1.20–1.73)	< 0.001	0.94(0.55–1.61)	0.81	0.036
Chronic bronchitis	1.83(1.25–2.67)	0.003	0	1.84(0.97–3.50)	0.06	2.94(0.63–13.65)	0.17	0.504
Bronchiectasis	0.96(0.73–1.28)	0.80	0	0.85(0.54–1.34)	0.48	0.86(0.28–2.61)	0.78	0.881

IPF, idiopathic pulmonary fibrosis; COPD, chronic obstructive pulmonary disease; *, the results were derived from MR-PRESSO after corrected outliers

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