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Table 3 Multivariable Mendelian randomization analyses of GERD with common risk factors for chronic respiratory diseases adjusting for potential mediators

From: Assessing the genetic relationship between gastroesophageal reflux disease and chronic respiratory diseases: a mendelian randomization study

Outcomes

Model

OR (95%CI)

P-value

Asthma

Unadjusted model

1.39(1.25–1.56)

< 0.001

Adjusted for Obesity (Class 1 and 2)

1.33(1.22–1.46)

< 0.001

Adjusted for Smoking initiation

1.41(1.24–1.62)

< 0.001

COPD

Unadjusted model

1.64(1.41–1.93)

< 0.001

Adjusted for Smoking initiation

1.27(1.10–1.47)

0.001

Adjusted for Smoking status (Current)

1.16(1.01–1.34)

0.030

Adjusted for Exposure to tobacco smoke outside home

1.67(1.40-2.00)

< 0.001

  1. COPD, chronic obstructive pulmonary disease; Obesity class 1, BMI: 30-34.9 kg/m2; Obesity class 2, BMI: 35-39.9 kg/m2
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BMC Pulmonary Medicine

ISSN: 1471-2466

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