An economic evaluation of two PCR-based respiratory panel assays for patients admitted to hospital with community-acquired pneumonia (CAP) in the UK, France and Spain

Table 4 Average cost of diagnostic testing per patient admitted with CAP in the UK, France, and Spain

Strategy	UK			France			Spain
Strategy	Base case	Low	High ^b	Base case	Low	High ^b	Base case	Low	High ^b
Immunocompetent patients
SoC	€ 85.99	€ 1.49	€ 695.95	€ 277.58	€ 5.40	€ 1,656.65	€ 127.85	€2.59	€ 1,460.85
Panel 1^a	€ 66.89	€ 12.24	€ 488.27	€ 245.75	€ 15.14	€ 1,265.30	€ 102.98	€ 12.85	€ 1,047.82
Panel 3	€ 81.81	€ 3.64	€ 467.80	€ 197.10	€ 15.24	€ 995.30	€ 120.40	€ 10.79	€ 1,007.07
Panel 1 + 3	€ 63.90	€ 14.39	€ 329.31	€ 177.98	€ 24.99	€ 803.95	€ 100.78	€ 21.05	€ 747.39
Difference between SoC and Panel 1 + 3^c	-€ 22.09	€ 12.89	-€ 366.64	-€ 99.60	€ 19.59	-€ 852.70	-€ 27.07	€ 18.46	-€ 713.46
Immunocompromised patients
SoC	€ 102.34	€ 1.79	€ 1,228.93	€ 379.96	€ 8.25	€ 2,931.50	€ 211.11	€8.80	€ 3,063.62
Panel 1^a	€ 87.42	€ 12.54	€ 982.75	€ 349.73	€ 16.99	€ 2,430.15	€ 177.55	€ 16.17	€ 2,558.24
Panel 3	€ 88.17	€ 5.01	€ 800.17	€ 292.81	€ 16.85	€ 1,870.15	€ 188.36	€ 17.46	€ 2,023.17
Panel 1 + 3	€ 76.23	€ 15.76	€ 636.61	€ 271.18	€ 25.59	€ 1,568.80	€ 159.24	€ 25.08	€ 1,738.49
Difference between SoC and Panel 1 + 3^c	-€ 26.12	€ 13.97	-€ 592.32	-€ 108.77	€ 17.34	-€ 1,362.70	-€ 51.87	€ 16.28	-€ 1,325.13

Abbreviations: SoC Standard of care, UK United Kingdom. Equivalent UK costs in UK £ are presented in Supplementary Table 14
^aPanel 1 strategy refers to the cost of using Respiratory 1 Panel to replace some SoC tests plus the cost of diagnostic tests not replaced by the panel. The equivalent is true for the Panel 3 strategy and for the Panel 1 + 3 strategy
^bFor respiratory panel strategies, the high value refers to 100% of people being tested with the relevant respiratory panel/s
^cA negative number here indicates that the Panel 1 + 3 strategy results in cost savings compared to SoC

ISSN: 1471-2466