Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study

BMC Pulmonary Medicine

Table 4 The association between serum 25(OH)D level, genotype and allele frequencies (in %) of VDR and VDBP gene variants in asthmatic subject

VDR gene variant	Genotype, major allele	25(OH)D level asthma group		25(OH)D level control group
VDR gene variant	Genotype, major allele	< 20 ng /ml n = 5	20–30 ng/ml n = 8	< 20 ng /ml n = 14	20–30 ng/ml n = 16
rs7975232	AA AC CC A allele	26 44 30 48	13 38 50 31	29 50 21	31 38 31
rs7975232	AA AC CC A allele	26 44 30 48	13 38 50 31	54	50
rs1544410	CC TC TT C	49 43 8 71	50 50 0 75	31 46 23	40 53 7
rs1544410	CC TC TT C	49 43 8 71	50 50 0 75	54	67
rs731236	AA AG GG A allele	52 42 6 71	50 50 0 75	31 46 23	39 54 8
rs731236	AA AG GG A allele	52 42 6 71	50 50 0 75	54	65
rs3847987	CC CA AA C allele	76 17 7 84	88 13 0 94	86 14 0	81 13 6
rs3847987	CC CA AA C allele	76 17 7 84	88 13 0 94	93	88
rs2228570	GG AG AA G allele	36 50 14 61	38 50 13 63	36 50 14	38 50 13
rs2228570	GG AG AA G allele	36 50 14 61	38 50 13 63	61	63
rs11168293	GG GT TT G allele	44 37 19 63*	13 38 50 31	43 36 21	38 44 19
rs11168293	GG GT TT G allele	44 37 19 63*	13 38 50 31	61	59
VDBP gene variant	GENOTYPE, MAJOR ALLELE	25(OH)D LEVEL IN ASTHMA GROUP		25(OH)D LEVEL IN CONTROL GROUP
VDBP gene variant	GENOTYPE, MAJOR ALLELE	< 20 ng/ml n = 54	20–30 ng/ml n = 8	< 20 ng/ml n = 14	20–30 ng/ml n = 16
rs4588	GG GT TT G allele	52 34 14 69	50 25 25 63	42	37
				58	56
				0	6
				71	66
rs7041	AA AC CC C allele	19 43 37 41	29 29 43 43	23 39 39	13 69 19
rs7041	AA AC CC C allele	19 43 37 41	29 29 43 43	42	47

*p < 0.05 compared vitamin D deficiency group with vitamin D insufficiency group in patients with asthma

ISSN: 1471-2466