From: Clinical significance of high monocyte counts for the continuous treatment with nintedanib
Total | With Adverse Event | Without Adverse Event | P-value | |
---|---|---|---|---|
(n = 111) | (n = 66) | (n = 45) | ||
Age (years) | 70 (66–75) | 70 (66–75.3) | 71 (65–75) | 0.7499 |
Male, n (%) | 80 (72.1) | 50 (75.8) | 30 (66.7) | 0.3890 |
IPF/PF-ILD/SSc-ILD | 59/35/17 | 38/17/11 | 21/18/6 | 0.3120 |
Dosage reduction | 47 | 47 | 0 | |
Dosage withdrawal | 33 | 33 | 0 | |
Dosage discontinuation | 21 | 21 | 0 | |
Smoking (pack-years) | 40 (20–57.6) | 40 (20–60) | 40 (19.3–56.8) | 0.9446 |
BMI (kg/m2) | 22.9 (20.6–25.2) | 23.2 (21.3–25.7) | 22.1 (19.7–24.5) | 0.0332 |
BSA (m2) | 1.62 (1.51–1.72) | 1.63 (1.56–1.73) | 1.56 (1.46–1.69) | 0.0471 |
Albumin | 3.87 (3.59–4.10) | 3.83 (3.52–4.10) | 3.90 (3.61–4.11) | 0.2898 |
C-reactive protein (mg/dL) | 0.28 (0.10–0.59) | 0.28 (0.10–0.77) | 0.28 (0.08–0.50) | 0.2382 |
KL-6 (U/mL) | 943 (633–1463) | 922 (626–1342) | 993 (645–1694) | 0.3663 |
White blood cell count (x109/L) | 7.400 (6.000–9.700) | 7.550 (6.375–9.725) | 6.800 (5.550–9.725) | 0.2170 |
Monocyte count (x109/L) | 0.451 (0.352–0.600) | 0.492 (0.385–0.630) | 0.410 (0.397–0.557) | 0.0178 |
mMRC score* | 1.62 ± 1.05 | 1.58 ± 0.16 | 1.65 ± 0.13 | 0.8867 |
FVC | 2.18 (1.61–2.86) | 2.18 (1.69–2.89) | 2.25 (1.54–2.85) | 0.8073 |
%FVC | 70.4 (57.1–87.4) | 70.4 (55.4–87.6) | 70.4 (59.3–83.5) | 0.7645 |
%DLco | 56.3 (44.8–73.7) | 55.8 (46.6–71.4) | 61.8 (44.4–76.9) | 0.3962 |
Starting dosage 300 mg (%) | 83 (74.8) | 55 (83.3) | 28 (62.2) | 0.0150 |