Elevation of D-dimer levels are associated with early need for mechanical ventilation support in patients with COVID-19

Table 1 Basic characteristics of COVID-19 patients (n = 110)

Variable	Total (n = 200)		Traditional Oxygen (n = 164)		Invasive MV (n = 36)		p
	Mean	SD	Mean	SD	Mean	SD
Age (Year)	59.25	12.96	57.42	13.11	67.77	14.9	< 0.001^†
	N	%	N	%	N	%
Male-sex	154	77	123	75	31	86.11	0.13ƪ
DM	77	37.5	63	38.41	14	38.89	0.91 ƪ
HTN	75	36.5	56	34.15	19	52.78	0.03 ƪ
IHD	9	3.5	6	3.66	3	8.33	0.22 ƪ
	Mean	SD	Mean	SD	Mean	SD
TLC (10⁹/L)	11.55	3.5	10.8	3.4	18.9	7.6	< 0.001^†
Lymphocyte (10⁹/L)	1.66	0.41	1.77	0.98	1.19	0.51	< 0.001^†
HB (mg/dL)	14.3	4.2	13.75	6.7	12.75	4.9	0.04^†
PLT (10⁹/L)	314.5	95	325	175.8	269.5	98.2	0.002^†
AST (IU/L)	47.5	13.2	39	11	82	32	< 0.001^†
ALT (IU/L)	59	21	55	29	67	27	0.05^†
Urea (mg/dL)	57	19	49	24	156.5	77.4	< 0.001^†
Creatinine (mg/dL)	1.2	0.4	1.1	0.4	1.8	0.7	< 0.001^†
D-dimer (µ/L)	956	242	733	360	6486	2710	< 0.001^†
Ferritin (ng/L)	986	233	779	210.5	2638	970.6	< 0.001^†
CRP (mg/dL)	99.4	22.6	78.7	19.2	234	93.7	< 0.001^†

Numerical data presented as mean and stander deviation, and categorical data as number and percentage, n: number, SD: stander deviation, IMV: invasive mechanical ventilation, DM: diabetes mellitus, HTN: hypertension, IHD: ischemic heart disease, TLC: total leukocyte count, HB: hemoglobin, PLT: platelets, AST: Aspartate transaminase, ALT: Alanine transaminase, CRP: C-reactive protein, †: independent t-test, ƪ: chi square test, p considered significant if ≤ 0.05

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