Elevation of D-dimer levels are associated with early need for mechanical ventilation support in patients with COVID-19

Table 2 Independent predictors for invasive ventilation demand

Factors	Coefficient	OR	95% CI	P
Un-adjusted
TLC (10⁹/L)	0.17	1.18	(1.0359,1.3541)	0.01
Lymphocyte (10⁹/L)	0.00	1.00	(0.9978,0.9998)	0.01
HB (mg/dL)	-0.39	0.68	(0.4382,1.0449)	0.07
PLT (10⁹/L)	-0.01	0.99	(0.9868,0.9992)	0.01
Urea (mg/dL)	0.01	1.01	(1.0000,1.0267)	0.04
D-dimer (µ/L)	0.00	1.00	(1.0001,1.0006)	0.001
CRP (mg/dL)	0.01	1.01	(1.0005,1.0162)	0.02
Adjusted
Age (Year)	-0.05	0.96	(0.8710,1.0492)	0.32
Male-Sex	-0.25	0.78	(0.0397,15.1616)	0.87
DM	0.93	2.54	(0.1848,34.8226)	0.48
HTN	0.44	1.56	(0.1665,14.5228)	0.70
IHD	0.60	1.82	(0.1171,28.3517)	0.67
TLC (10⁹/L)	0.15	1.16	(0.9888,1.3665)	0.05
Lymphocyte (10⁹/L)	0.00	1.00	(0.9973,1.0002)	0.05
HB (mg/dL)	-0.48	0.62	(0.3531,1.0805)	0.08
PLT (10⁹/L)	-0.01	0.99	(0.9769,1.0001)	0.01
AST (IU/L)	0.00	1.00	(0.9886,1.0100)	0.90
ALT (IU/L)	0.00	1.00	(0.9957,1.0077)	0.68
Urea (mg/dL)	0.02	1.02	(0.9960,1.0466)	0.07
D-dimer (µ/L)	0.00	1.00	(1.0002,1.0009)	0.001
CRP (mg/dL)	0.01	1.01	(0.9997,1.0254)	0.03

Test of fitness: Hosmer-Lemeshow X2 = 1.01, p = 0.99, OR: odd ratio, CI: Confidence interval, DM: diabetes mellitus, HTN: hypertension, IHD: ischemic heart disease, TLC: total leukocyte count, HB: hemoglobin, PLT: platelets, AST: Aspartate transaminase, ALT: Alanine transaminase, CRP: C-reactive protein, Test of significant: Logistic regression analysis with adjusted and un-adjusted models, p considered significant if ≤ 0.05

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