Table 4 110 cases of drug-induced lung disorder due to olaparib from PMDA database from 2018 to 2021

Sex

Male

2

(1.8)

Event

Interstitial lung disease

98

(89.1)

[ n (%)]

Female

108

(98.2)

[ n (%)]

Lung failure

5

(4.5)

Pneumonitis

3

(2.7)

Age

30s

1

(0.9)

Pulmonary toxicity

3

(2.7)

[ n (%)]

40s

8

(7.3)

Alveolar hemorrhage

1

(0.9)

50s

19

(17.3)

60s

27

(24.5)

Time to event

median

120

70s

33

(30.0)

(days, n=79)

minimun

7

80s

6

(5.5)

maximun

740

unknown

16

(14.5)

Olaparib

Abort

94

(85.5)

Disease

Ovary

90

(81.8)

administration

Resume after abort

7

(6.4)

[ n (%)]

Peritoneum

9

(8.2)

[ n (%)]

Not changed

5

(4.5)

Breast

7

(6.4)

unknown

4

(3.6)

Pancreas

1

(0.9)

Prostate

1

(0.9)

Outcome

Recovery

39

(35.5)

unknown

2

(1.8)

[ n (%)]

Remission

34

(30.9)

Not recovered

2

(1.8)

Death

2

(1.8)

unknown

33

(30.0)