A randomized, double-blinded, placebo-controlled clinical trial of duloxetine hydrochloride enteric-coated tablets in the treatment of refractory chronic cough

Table 1 Outline of planned visit

Timepoint	Study period
	Screening visit	Randomize	Treatment visits							Post-treatment follow-up
	−7 days	Day 0	Visit 1(phone interview)	Visit 2(phone interview)	Visit 3	Visit 4	Visit 5	Visit 6	Visit 7	Visit 8
			Day 3	Week 1	Week 2	Week 3	Week 4	Week 5	Week 6	Week 7
Eligibility screen	✔
Informed consent	✔
Adverse event check			✔	✔	✔	✔	✔	✔	✔	✔
VAS			✔	✔	✔	✔	✔	✔	✔	✔
Cough symptom score	✔		✔	✔	✔	✔	✔	✔	✔	✔
Objective cough frequency	✔				✔	✔	✔	✔	✔	✔
CET	✔		✔	✔	✔	✔	✔	✔	✔	✔
LCQ	✔				✔	✔	✔	✔	✔	✔
PHQ-9	✔				✔	✔	✔	✔	✔	✔
MDI	✔				✔	✔	✔	✔	✔	✔
GAD-7	✔				✔	✔	✔	✔	✔	✔
LES-32	✔				✔	✔	✔	✔	✔	✔
Induction sputum	✔				✔	✔	✔	✔	✔	✔
Capsaicin cough sensitivity	✔				✔	✔	✔	✔	✔	✔

Notes: VAS visual analog scale, LCQ Leicester Cough Questionnaire, CET cough evaluation test, PHQ-9 Patient Health Questionnaire-9, MDI Major Depression Inventory, GAD-7 the Generalized Anxiety Disorder-7 scale, LES-32 Life Events Scale

ISSN: 1471-2466