Retrospective analysis of pulmonary cryptococcosis and extrapulmonary cryptococcosis in a chinese tertiary hospital

Table 2 Etiological detection tests of patients with cryptococcosis

Test items	Pulmonary cryptococcosis		Extrapulmonary cryptococcosis
Test items	Surgical	Nonsurgical ^b	Intracranial cryptococcosis	Cryptococcemia
Serum LFA	40% (2/5)	86.7% (13/15)	100% (6/6)	100% (1/1)
CSF LFA	--	0% (0/5)	100% (5/5)	--
Serum LA	100% (1/1)	100% (6/6)	--	100% (1/1)
CSF LA	--	--	100% (2/2)	--
Serum GXM	100% (1/1)	100% (7/7)	100% (2/2)	--
CSF culture	0% (0/1)	0% (0/2)	45.5% (5/11)	--
India ink test	0% (0/2)	0% (0/5)	54.5% (6/11)	--
Pathology	100% (32/32)	100% (23/23)	100% (1/1)	--
Blood culture	--	--	0 (0/10)	100% (5/5)^a
Bone marrow culture	--	--	0 (0/1)	100% (1/1)^a

All the tests were conducted before antifungal therapy or surgical resection. All the data were presented as percentage (positive population/ total detected population). Among 11 patients with intracranial cryptococcosis, 5 didn’t have chest CT scan. None of EPC patients underwent pulmonary pathological and microbiological examinations to diagnose PC. Some subjects in PC/EPC group were positive for more than one tests. Detailed data can be obtained from the first author
--: Nobody in the cohort had specified test results
GXM: capsular polysaccharide glucuronoxylomannan
^aOne patient has both blood culture and bone marrow culture positive for Cryptococcus
^bNonsurgical PC patients were generally treated in respiratory ward and diagnosed via percutaneous lung biopsy

ISSN: 1471-2466