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Fig. 8 | BMC Pulmonary Medicine

Fig. 8

From: Tetramethylpyrazine ameliorates endotoxin-induced acute lung injury by relieving Golgi stress via the Nrf2/HO-1 signaling pathway

Fig. 8

Graphical illustration of TMP pretreatment-mediated preservation of Golgi stress involved in regulating Nrf2/HO-1 signaling pathway. When LPS was administrated to C57BL/6J mice or MLE12 alveolar epithelial cells, TMP activated Nrf2/HO-1 pathway, leading to Nrf2 transferred from the cytoplasm to the nucleus, and increased the ARE response to induce target gene of HO-1 expression. Meanwhile, pretreatment of TMP upregulated the expressions of Golgi stress markers GM130, Golgin97, and ATP2C1, yet down-regulated the expression of Golgi stress-inducible protein GOLPH3. In conclusion, TMP pretreatment alleviates Golgi stress in endotoxin-related acute lung injury, thus alleviating the inflammation and oxidative stress of lung tissue, then reducing cell apoptosis or death

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BMC Pulmonary Medicine

ISSN: 1471-2466

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