Table 3 Ventilatory settings and monitoring variables

Variable

All cohort (n=51)

Dead (n=26)

Alive (n=25)

p value

Pre-ECMO

 Vt (ml/kg PBW)

5.6 (4.8-6.6)

5.3 (4.1-6.2)

5.8 (4.9-6.6)

0.209

 Pplat (cm H₂O)

29.0 (25.3-34.0)

29.0 (25.0-34.0)

29.0 (24.5-34.5)

0.916

 DP (cm H₂O)

19.5 (16.0-27.0)

21.0 (17.0-27.0)

17.0 (14.0-26.5)

0.216

 C_RS (ml/cm H₂O)

19.3 (12.0-27.3)

14.9 (10.8-22.8)

21.9 (13.6-29.4)

0.113

 RR (min^-1)

24.0 (20.0-28.0)

25.0 (20.0-29.5)

24.0 (19.0-26.3)

0.279

 PEEP (cm H₂O)

8.0 (5.0-10.0)

7.0 (5.0-9.0)

8.0 (4.0-13.5)

0.376

 Power (J/min)

23.8 (16.2-30.3)

21.8 (15.9-26.2)

25.7 (16.5-34.7)

0.192

24h on ECMO

 Vt (ml/kg PBW)

3.5 (2.5-4.3)

3.1 (2.3-4.1)

3.8 (2.9-4.4)

0.347

 Pplat (cm H₂O)

23.0 (20.0-26.0)

25.5 (21.0-29.5)

21.5 (19.0-23.8)

0.019*

 DP (cm H₂O)

15.0 (11.3-19.0)

17.0 (13.0-20.8)

12.5 (10.0-17.8)

0.024*

 C_RS (ml/cm H₂O)

15.5 (10.2-21.9)

12.1 (8.5-17.2)

19.3 (13.9-26.7)

0.010*

 RR (min^-1)

14.5 (10.0-15.0)

15.0 (11.5-16.0)

13.0 (10.0-15.0)

0.233

 PEEP (cm H₂O)

7.0 (5.0-10.0)

7.5 (5.0-10.0)

7.0 (5.0-12.0)

0.680

 Power (J/min)

5.6 (3.5-7.5)

5.5 (3.3-7.4)

5.6 (3.8-7.8)

0.815

48h on ECMO

 Vt (ml/kg PBW)

4.2 (2.8-5.3)

3.8 (2.1-4.7)

4.6 (3.4-5.5)

0.074

 Pplat (cm H₂O)

23.0 (19.3-26.8)

24.0 (21.0-29.5)

21.0 (19.0-25.0)

0.018*

 DP (cm H₂O)

14.0 (12.0-17.5)

14.0 (13.0-23.0)

12.0 (10.0-16.0)

0.014*

 C_RS (ml/cm H₂O)

17.3 (11.3-26.9)

11.8 (7.5-21.0)

22.6 (16.6-31.7)

0.003*

 RR (min^-1)

15.0 (11.0-16.0)

15.0 (14.0-15.3)

13.0 (10.0-16.0)

0.277

 PEEP (cm H₂O)

8.0 (5.0-10.0)

8.0 (5.0-10.0)

8.0 (5.0-11.0)

0.609

 Power (J/min)

6.3 (5.1-10.4)

6.1 (3.9-11.4)

6.7 (5.2-8.9)

0.613

ARDS cohort (n=33)

ARDS dead (n=20)

ARDS alive (n=13)

p value

Pre-ECMO

 Vt (ml/kg)

5.8 (5.0-7.1)

5.8 (4.8-7.1)

6.4 (5.5-7.6)

0.239

 Pplat (cm H₂O)

29.0 (26.0-34.0)

29.0 (25.0-33.0)

30.0 (26.3-35.8)

0.489

 DP (cm H₂O)

18.0 (16.0-25.0)

20.0 (17.0-27.0)

17.0 (14.5-20.3)

0.073

 C_RS (ml/cm H₂O)

21.4 (14.2-28.9)

16.1 (10.9-22.8)

24.1 (21.2-31.3)

0.043*

 RR (min^-1)

24.0 (20.0-28.0)

25.0 (20.0-30.0)

24.0 (18.0-24.5)

0.072

 PEEP (cm H₂O)

8.0 (5.0-14.0)

7.0 (5.0-9.0)

11.0 (8.3-17.5)

0.007*

 Power (J/min)

25.6 (17.4-30.9)

24.4 (17.4-29.6)

27.1 (19.1-37.2)

0.168

24h on ECMO

 Vt (ml/kg)

3.6 (2.5-4.5)

3.6 (2.5-4.5)

3.7 (2.9-4.9)

0.774

 Pplat (cm H₂O)

23.0 (20.3-27.8)

26.0 (21.0-30.0)

22.0 (19.0-24.5)

0.148

 DP (cm H₂O)

14.0 (11.0-18.0)

16.0 (13.0-20.0)

11.0 (8.0-15.0)

0.020*

 C_RS (ml/cm H₂O)

18.0 (10.5-25.2)

12.6 (9.7-19.7)

22.3 (18.8-28.9)

0.025*

 RR (min^-1)

14.0 (10.5-15.0)

15.0 (13.0-16.0)

13.0 (10.0-15.0)

0.226

 PEEP (cm H₂O)

9.5 (6.3-12.0)

8.0 (6.0-10.0)

12.0 (6.5-13.0)

0.132

 Power (J/min)

6.1 (4.2-8.4)

6.2 (4.7-9.4)

5.9 (3.9-8.3)

0.803

48h on ECMO

 Vt (ml/kg)

4.3 (3.2-5.5)

4.1 (2.2-5.4)

4.7 (3.8-5.5)

0.313

 Pplat (cm H₂O)

23.5 (21.0-26.8)

24.0 (21.0-28.0)

23.0 (20.3-26.0)

0.261

 DP (cm H₂O)

14.0 (12.0-16.0)

14.0 (13.0-18.8)

12.5 (9.0-16.0)

0.107

 C_RS (ml/cm H₂O)

19.1 (11.9-28.5)

16.1 (8.5-26.1)

24.8 (18.3-31.0)

0.037*

 RR (min^-1)

15.0 (12.0-16.0)

15.0 (14.0-15.8)

13.0 (10.5-16.0)

0.286

 PEEP (cm H₂O)

8.0 (7.0-12.0)

8.0 (7.0-10.8)

10.0 (7.5-13.0)

0.268

 Power (J/min)

7.7 (5.3-11.6)

6.8 (5.1-12.1)

8.6 (5.4-10.6)

0.816