Table 3 Specific relative risk of RA incidence, mortality, and DALY rate due to age, period, and cohort effects

Age

 4–9

0.137 (0.054, 0.345) **

0.116 (0.059, 0.229) **

0.143 (0, 4818.51)

0.112 (0, 1007.802)

0.065 (0.025, 0.167) **

0.045 (0.021, 0.099) **

 10–14

0.360 (0.209, 0.621) **

0.356 (0.244, 0.519) **

0.167 (0, 652.024)

0.105 (0, 301.362)

0.157 (0.090, 0.273) **

0.125 (0.081, 0.192) **

 15–19

0.527 (0.334, 0.832) *

0.597 (0.442, 0.807) *

0.124 (0, 633.349)

0.12 (0, 112.347)

0.265 (0.173, 0.406) **

0.268 (0.198, 0.364) **

 20–24

0.627 (0.412, 0.953) *

0.773 (0.592, 1.011)

0.120 (0, 333.690)

0.125 (0, 59.512)

0.399 (0.281, 0.567) **

0.439 (0.343, 0.562) **

 25–29

0.669 (0.447, 1.001)

0.890 (0.692, 1.143)

0.133 (0, 148.301)

0.155 (0.001, 28.374)

0.526 (0.386, 0.715) **

0.613 (0.495, 0.759) **

 30–34

0.819 (0.566, 1.184)

1.091 (0.867, 1.373)

0.176 (0, 62.476)

0.218 (0.003, 15.768)

0.656 (0.498, 0.864) *

0.795 (0.657, 0.960) *

 35–39

1.065 (0.764, 1.486)

1.377 (1.117, 1.699) *

0.239 (0.002, 35.382)

0.264 (0.006, 11.313)

0.816 (0.637, 1.045)

0.993 (0.838, 1.176)

 40–44

1.404 (1.042, 1.893) *

1.691 (1.395, 2.050) **

0.383 (0.007, 22.212)

0.418 (0.020, 8.735)

1.023 (0.822, 1.274)

1.240 (1.068, 1.440) *

 45–49

1.800 (1.377, 2.353) **

2.023 (1.695, 2.416) **

0.536 (0.018, 15.93)

0.716 (0.063, 8.119)

1.268 (1.046, 1.536) *

1.540 (1.352, 1.755) **

 50–54

2.083 (1.630, 2.662) **

2.301 (1.951, 2.713) **

0.864 (0.057, 12.981)

1.017 (0.140, 7.393)

1.581 (1.339, 1.867) **

1.827 (1.630, 2.046) **

 55–59

2.297 (1.832, 2.879) **

2.534 (2.170, 2.959) **

1.467 (0.177, 12.163)

1.651 (0.348, 7.824)

1.941 (1.683, 2.237) **

2.163 (1.961, 2.385) **

 60–64

2.569 (2.089, 3.160) **

2.799 (2.418, 3.239) **

2.692 (0.534, 13.568)

2.848 (0.853, 9.514)

2.405 (2.131, 2.715) **

2.564 (2.356, 2.790) **

 65–69

2.630 (2.164, 3.197) **

2.613 (2.260, 3.022) **

4.157 (1.118, 15.465) *

4.548 (1.67, 12.385) *

2.775 (2.494, 3.087) **

2.895 (2.685, 3.122) **

 70–74

2.226 (1.825, 2.715) **

1.945 (1.665, 2.273) **

6.464 (1.865, 22.399) *

6.432 (2.371, 17.449) **

3.035 (2.744, 3.357) **

2.910 (2.704, 3.132) **

 75–79

1.630 (1.312, 2.025) **

1.231 (1.029, 1.474) *

9.551 (2.284, 39.936) *

8.787 (2.705, 28.539) **

3.111 (2.801, 3.456) **

2.741 (2.535, 2.963) **

 80–84

1.134 (0.885, 1.452)

0.752 (0.606, 0.932) *

11.608 (1.932, 69.751) *

10.909 (2.498, 47.65) *

2.772 (2.460, 3.123) **

2.380 (2.178, 2.600) **

 85–89

0.754 (0.564, 1.008)

0.512 (0.399, 0.658) **

16.086 (1.716, 150.776) *

12.400 (1.991, 77.238) *

2.572 (2.240, 2.952) **

1.943 (1.752, 2.154) **

 90–94

0.415 (0.282, 0.611) **

0.291 (0.208, 0.406) **

14.926 (0.971, 229.339)

12.807 (1.397, 117.42) *

1.846 (1.563, 2.180) **

1.504 (1.329, 1.701) **

Period

 1990–1994

0.850 (0.737, 0.98) *

0.879 (0.797, 0.970) *

0.766 (0.183, 3.208)

0.793 (0.261, 2.416)

0.771 (0.704, 0.844) **

0.781 (0.732, 0.832) **

 1995–1999

0.910 (0.799, 1.038)

0.931 (0.849, 1.021)

0.828 (0.339, 2.021)

0.846 (0.422, 1.694)

0.846 (0.789, 0.907) **

0.857 (0.816, 0.901) **

 2000–2004

0.973 (0.858, 1.103)

0.982 (0.898, 1.073)

0.967 (0.636, 1.472)

0.952 (0.684, 1.325)

0.963 (0.909, 1.021)

0.959 (0.920, 1.000)

 2005–2009

1.040 (0.917, 1.180)

1.035 (0.947, 1.132)

1.057 (0.692, 1.614)

1.018 (0.728, 1.425)

1.063 (1.002, 1.128)

1.050 (1.006, 1.096) *

 2010–2014

1.105 (0.971, 1.257)

1.087 (0.993, 1.19) *

1.169 (0.48, 2.847)

1.140 (0.569, 2.284)

1.173 (1.094, 1.257) **

1.163 (1.107, 1.223) **

 2015–2019

1.156 (1.011, 1.323) *

1.106 (1.007, 1.216) *

1.319 (0.32, 5.432)

1.348 (0.448, 4.054)

1.277 (1.174, 1.390) **

1.275 (1.200, 1.354) **

Birth Cohort

 1900–1904

1.841 (0.796, 4.26)

1.578 (0.752, 3.315)

4.612 (0.147, 144.899)

4.297 (0.285, 64.841)

2.947 (2.236, 3.885) **

2.779 (2.255, 3.425) **

 1905–1909

1.747 (1.03, 2.964) *

1.524 (0.958, 2.422)

3.969 (0.215, 73.443)

3.928 (0.393, 39.214)

2.600 (2.092, 3.232) **

2.551 (2.165, 3.006) **

 1910–1914

1.629 (1.091, 2.431) *

1.434 (1.010, 2.037) *

3.409 (0.297, 39.179)

3.517 (0.511, 24.186)

2.303 (1.911, 2.776) **

2.302 (2.001, 2.649) **

 1915–1919

1.558 (1.128, 2.152) *

1.370 (1.037, 1.81) *

3.272 (0.436, 24.539)

3.373 (0.684, 16.629)

2.200 (1.868, 2.591) **

2.178 (1.924, 2.465) **

 1920–1924

1.42 (1.077, 1.874) *

1.268 (1.004, 1.602) *

2.958 (0.555, 15.773)

3.025 (0.802, 11.415)

1.986 (1.711, 2.306) **

1.956 (1.747, 2.191) **

 1925–1929

1.303 (1.016, 1.67) *

1.174 (0.956, 1.442)

2.698 (0.621, 11.721)

2.686 (0.839, 8.597)

1.806 (1.568, 2.079) **

1.760 (1.581, 1.959) **

 1930–1934

1.224 (0.963, 1.557)

1.157 (0.954, 1.403)

2.487 (0.566, 10.931)

2.465 (0.769, 7.897)

1.665 (1.444, 1.921) **

1.634 (1.466, 1.821) **

 1935–1939

1.151 (0.903, 1.466)

1.126 (0.933, 1.359)

2.171 (0.396, 11.900)

2.220 (0.592, 8.333)

1.496 (1.285, 1.743) **

1.490 (1.330, 1.669) **

 1940–1944

1.129 (0.882, 1.445)

1.124 (0.934, 1.353)

1.899 (0.241, 14.941)

1.939 (0.393, 9.563)

1.375 (1.164, 1.623) **

1.370 (1.212, 1.549) **

 1945–1949

1.077 (0.832, 1.394)

1.098 (0.911, 1.324)

1.655 (0.133, 20.541)

1.686 (0.242, 11.733)

1.250 (1.039, 1.504) *

1.257 (1.099, 1.438) *

 1950–1954

1.006 (0.762, 1.326)

1.042 (0.859, 1.265)

1.401 (0.067, 29.278)

1.461 (0.142, 15.036)

1.122 (0.913, 1.380)

1.134 (0.977, 1.315)

 1955–1959

0.956 (0.709, 1.291)

0.996 (0.812, 1.222)

1.192 (0.032, 44.361)

1.241 (0.078, 19.804)

1.019 (0.809, 1.283)

1.026 (0.870, 1.209)

 1960–1964

0.919 (0.664, 1.271)

0.959 (0.772, 1.191)

1.031 (0.015, 73.179)

1.054 (0.041, 27.102)

0.936 (0.725, 1.209)

0.935 (0.780, 1.121)

 1965–1969

0.879 (0.62, 1.248)

0.923 (0.733, 1.162)

0.892 (0.006, 126.256)

0.890 (0.021, 38.181)

0.858 (0.648, 1.137)

0.850 (0.696, 1.037)

 1970–1974

0.848 (0.583, 1.233)

0.886 (0.694, 1.131)

0.729 (0.002, 225.012)

0.725 (0.010, 54.871)

0.779 (0.573, 1.060)

0.769 (0.619, 0.956)

 1975–1979

0.817 (0.547, 1.219)

0.854 (0.659, 1.106)

0.593 (0.001, 407.845)

0.575 (0.004, 86.886)

0.710 (0.508, 0.993) *

0.698 (0.551, 0.885)

 1980–1984

0.786 (0.513, 1.205)

0.829 (0.629, 1.092)

0.484 (0, 687.804)

0.446 (0.001, 145.058)

0.651 (0.452, 0.937) *

0.638 (0.492, 0.826)

 1985–1989

0.755 (0.475, 1.201)

0.806 (0.597, 1.088)

0.411 (0, 1005.372)

0.367 (0.001, 210)

0.598 (0.400, 0.893) *

0.583 (0.438, 0.777) **

 1990–1994

0.727 (0.430, 1.227)

0.779 (0.553, 1.096)

0.321 (0, 3807.187)

0.296 (0, 704.455)

0.538 (0.338, 0.857) *

0.528 (0.378, 0.736) **

 1995–1999

0.699 (0.382, 1.28)

0.752 (0.503, 1.124)

0.254 (0, 17479.761)

0.240 (0, 3190.05)

0.478 (0.270, 0.845) *

0.471 (0.312, 0.711) **

 2000–2004

0.663 (0.312, 1.411)

0.721 (0.432, 1.206)

0.202 (0, 139728.984)

0.201 (0, 22633.582)

0.411 (0.190, 0.889) *

0.415 (0.235, 0.733) *

 2005–2009

0.621 (0.21, 1.835)

0.690 (0.322, 1.481)

0.152 (0, 5253578.387)

0.161 (0, 853550.511)

0.332 (0.099, 1.112)

0.356 (0.139, 0.908) *

 2010–2014

0.579 (0.057, 5.871)

0.653 (0.117, 3.639)

0.110 (0, 6398086005975.39)

0.129 (0, 10756434816.291)

0.242 (0.015, 3.941)

0.288 (0.033, 2.504)

Deviance

0.140

0.124

0.065

0.097

0.798

1.399

AIC

4.804

5.475

2.288

2.591

5.929

6.632

BIC

-299.517

-299.532

-299.592

-299.559

-298.85889

-298.257