Variable | HFNC success (n = 115) | HFNC failure (n = 133) | P value |
---|---|---|---|
Age, y | 57 [52–70] | 64 [55–71.5] | 0.016 |
Sex, male (%) | 87 (75.7) | 103 (77.4) | 0.74 |
BMI, kg/m2 | 25.8 ± 4.6 | 26.1 ± 5.1 | 0.67 |
Smoking history, past or current (%) | 76 (66.1) | 86 (65.3) | 0.81 |
Past medical history, number (%) | |||
 Asthma | 10 (8.7) | 9 (6.8) | 0.57 |
 COPD | 4 (3.5) | 28 (13.5) | 0.004 |
 Interstitial Pneumonia | 0 (0) | 3 (2.3) | 0.52 |
 Malignancy | 9 (7.8) | 10 (7.5) | 0.93 |
 HIV infection, AIDS | 0 (0) | 1 (0.8) | 0.26 |
 Diabetes mellitus | 23 (20.0) | 43 (32.3) | 0.03 |
 Chronic kidney disease | 14 (12.2) | 9 (6.8) | 0.14 |
 Hemodialysis | 1 (0.9) | 1 (0.8) | 0.91 |
 Cardiovascular disease | 13 (11.3) | 22 (16.5) | 0.23 |
 Hypertension | 60 (52.2) | 65 (48.9) | 0.60 |
 Chronic liver disease | 7 (6.1) | 12 (9.0) | 0.38 |
 Cerebrovascular disease | 8 (7.0) | 12 (9.0) | 0.55 |
Vital signs on admission | |||
 Mean arterial pressure | 101.2 ± 14.0 | 99.8 ± 13.0 | 0.44 |
 Heart rate | 89 ± 17 | 90 ± 18 | 0.63 |
 Respiratory rate | 24 ± 6 | 27 ± 7 | 0.03 |
 Consciousness disorder (GCS score < 15), (%) | 8 (7.0) | 17 (12.9) | 0.11 |
Laboratory test results | |||
 White blood cell count, × 103/µL | 7.4 [5.2–10.4] | 6.5 [4.65–9.4] | 0.08 |
 Lymphocyte count, /µL | 608 [426–840] | 487 [350–730] | 0.01 |
 Hct level, % | 41.1 ± 4.2 | 40.3 ± 5.3 | 0.63 |
 Serum albumin level, g/dL | 3.0 ± 0.4 | 2.9 ± 0.4 | 0.39 |
 Lactate dehydrogenase level, IU/L | 423 [345–548] | 521 [441–662] |  < 0.0001 |
 Na level, mEq/L | 135.8 ± 4.3 | 135.6 ± 4.4 | 0.90 |
 K level, mEq/L | 4.08 ± 0.56 | 4.08 ± 0.56 | 0.73 |
 Creatinine level, mg/dL | 0.75 [0.63–0.98] | 0.83 [0.67–1.05] | 0.07 |
 C-reactive protein level, mg/dL | 8.24 [4.68–12.78] | 9.19 [5.045–12.495] | 0.73 |