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Table 2 Results of a multivariable logistic regression analysis with all risk factors (DOATS) and with all but oxygen saturation (DOAT) before and after optimism correction with 200 cycles of bootstrapping in the original cohort

From: Development and external validation of the DOAT and DOATS scores: simple decision support tools to identify disease progression among nonelderly patients with mild/moderate COVID-19

Variable

DOATS-based original model

 

DOAT-based original model

Before optimism correction

After optimism correction

 

Before optimism correction

After optimism correction

β coefficient

95% CI

β coefficient

95% CI

 

β coefficient

95% CI

β coefficient

95% CI

Intercept

23.407

9.458–37.356

21.921

21.731–22.111

 

-5.217

-5.882–-4.553

-5.136

-5.325–-4.947

Age, years

0.043

0.036–0.050

0.041

0.034–0.047

 

0.049

0.041–0.058

0.046

0.038–0.055

Temperature, °C

         

37.0–37.9

0.283

-0.280–0.847

0.268

-0.266–0.801

 

0.381

-0.168–0.931

0.359

-0.159–0.877

≥ 38.0

1.671

1.298–2.043

1.580

1.228–1.933

 

1.825

0.000–1.452

1.719

0.000–1.367

Diabetes or obesity

0.987

0.298–1.675

0.933

0.282–1.585

 

1.134

0.458–1.810

1.068

0.432–1.705

SpO2, %

-0.291

-0.435–-0.147

-0.275

-0.411–-0.139

 

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  1. confidence interval, CI; comorbidities of diabetes/obesity, age, body temperature, and oxygen saturation, DOATS; comorbidities of diabetes/obesity, age, and body temperature, DOAT