Fig. 1

Pathological and genomic features of pulmonary inflammatory leiomyosarcoma. a Macroscopically, the tumor was observed as a well-demarcated firm white mass. b Histologically, the tumor was focally encapsulated by a fibrous capsule at low magnification. c Tumor cells had eosinophilic cytoplasm and blunt-ended nuclei arranged in intersecting fascicles with scattered foamy histiocytes at high magnification. d Tumor cells were focally positive for desmin. e A few neoplastic cells were weakly positive for h-caldesmon. f Numerous histiocytic infiltrations were highlighted upon CD163 immunohistochemical analysis. e, Sanger sequencing revealed the MUC3A gene alteration p. S811P (c. 2431 T > C).