Fig. 2

DNA methylation profile of pulmonary inflammatory leiomyosarcoma. a Using t-distributed stochastic neighbor embedding, our case (red square) was plotted in the vicinity of inflammatory myofibroblastic tumors (IMTs). The color code used for 62 reference tumors and three control DNA methylation classes is the same as that described in the article by Koelsche et al. [9]; AFH: angiomatoid fibrous histiocytoma and LCH: Langerhans cell histiocytosis. The methylation class leiomyosarcoma is indicated in the left panel. b A copy number plot derived from DNA methylome data demonstrates a relatively silent chromosomal copy number status. c The immune cell profile of PILMS shows a larger fraction of monocytes and a smaller fraction of neutrophils as compared to IMT.