Table 6 Comparison of patient groups: treatment initiated ≤ 1 year versus > 1 year (patients diagnosed 1.6.2013 or after included). Data are presented as mean ± sd unless otherwise stated
Variable | Initiation ≤ 1 y (N = 60) | Initiation > 1 y (N = 32) | p-value |
|---|---|---|---|
Age at diagnosis(years) | 70.0 ± 6.1 | 68.6 ± 8.5 | 0.41 |
50–65 years N (%) | 12 (21.1%) | 7 (23.3%) | 0.91 |
66–75 years N (%) | 31 (54.4%) | 15 (50.0%) | |
> 75 years N (%) | 14 (24.6%) | 8 (26.7%) | |
Gender | |||
Male N (%) | 46 (76.7%) | 20 (62.5%) | 0.15 |
Female N (%) | 14 (23.3%) | 12 (37.5%) | |
BMI (kg/m2) median | 27.1(25.0, 30.6) | 28.4(26.0,31.6) | 0.36 |
FVC (% of predicted) | 70.1 ± 12.4 | 84.0 ± 12.8 | < 0.001 |
FVC ≤ 75% N (%) | 24 (63.1%) | 7 (23.3%) | 0.001 |
FVC > 75% N (%) | 14 (36.8%) | 23 (76.7%) | |
DLCO/VA/VA (% of predicted) | 55.6 ± 14.6 | 60.1 ± 12.1 | 0.11 |
DLCO/VA ≤ 55 N (%) | 18 (54.6%) | 10 (35.7%) | 0.20 |
DLCO/VA > 55 N (%) | 15 (45.5%) | 18 (64.3%) | |
Smoking at diagnosis | 0.13 | ||
Never smoker N (%) | 20 (35.1%) | 13 (41.9%) | |
Current smoker N (%) | 3 (5.3%) | 5 (16.1%) | |
Ex-smoker N (%) | 34 (59.7%) | 13 (41.9%) | |
Number of medications at diagnosis (other than antifibrotic) median | 6.0 (3.0,9.0) | 6.0 (5.0,9.0) | 0.96 |
0–1 medication N (%) | 6 (10,0%) | 3 (9.4%) | 0.54 |
2–4 medications N (%) | 13 (21.7%) | 4 (12.5%) | |
≥ 5 medications N (%) | 41 (68.3%) | 25 (78.1%) | |